Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion |
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| Authors: | Krylatov A V Ugdyzhekova D S Bernatskaya N A Maslov L N Mekhoulam R Pertwee R G Stephano G B |
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| Institution: | (1) Institute of Cardiology, Tomsk Scientific Center, Siberian Division of Russian Academy of Medical Sciences, Russia;(2) Tomsk State Pedagogical University, Russia;(3) Jerusalem University, Jerusalem, Israel;(4) University of Aberdeen, Aberdeen, UK;(5) Stony Brook University, New York, USA |
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| Abstract: | Preliminary intravenous injection of cannabinoid receptor agonist HU-210 (0.05 mg/kg) reduced the incidence of ventricular arrhythmias during 10-min coronary occlusion and 10-min reperfusion in chloralose-anesthetized rats. Preliminary injection of type I cannabinoid receptor antagonist SR 141716A (3 mg/kg) had no effect on the antiarrhythmic effect of HU-210, while type II cannabinoid receptor antagonist SR 144528 (1 mg/kg) completely abolished the effect of HU-210. Preconditioning with glibenclamide (0.3 mg/kg), an inhibitor of ATP-dependent K+-channels, did not affect the antiarrhythmic activity of HU-210. These findings suggest that antiarrhythmic effect of HU-210 is mediated through activation of type II cannabinoid receptors rather than activation of K+-channels. |
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| Keywords: | arrhythmias cannabinoid receptors K+ channels |
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