推桥弓手法对食蟹猴轻度颈动脉粥样硬化模型血流动力学的影响

目的 探讨推桥弓手法对食蟹猴轻度颈动脉粥样硬化模型血流动力学的影响.方法 选取9只正常食蟹猴,并随机分为3组(每组3只):推桥弓组、模型对照组、空白对照组.对推桥弓组和模型对照组食蟹猴建立轻度颈动脉粥样硬化模型,然后,对推桥弓组给予相应手法干预,最后对3组的颈动脉血管情况以及血流动力学进行对比评价.结果(1)在彩超检查中,推桥弓组、模型对照组可见斑块形成,同时,在血管横切面面积、斑块横切面面积、斑块狭窄率方面,与空白对照组比较,推桥弓组、模型对照组差异有统计学意义(P<0.05),而推桥弓组和模型对照组比较,差异无统计学意义(P>0.05).(2)在各项血流动力学指标中,与空白对照组对比,推桥弓组、模型对照组差异有统计学意义(P<0.05),而推桥弓组和模型对照组比较,差异无统计学意义(P>0.05).结论 粥样硬化斑块对颈动脉的血流动力学会产生影响,但推桥弓手法在短期内不会影响斑块的稳定性,也不会加重血流动力学的影响.

Effect of pushing manipulation on Qiaogong acupoint on hemodynamics in cynomolgus monkeys with mild carotid atherosclerotic plaques

Objective To explore the hemodynamic changes in cynomolgus monkeys with mild carotid atherosclerotic (CAS) plaques after therapy with pushing manipulation on Qiaogong acupoint (MPQ). Methods Nine cynomolgus monkeys were equally randomized into MPQ group,mild CAS model group and blank control group.Mild CAS models were established in the monkeys in MPQ and model groups,and the monkeys in MPQ group received treatment with MPQ intervention after the modeling. The conditions of the carotid artery and the hemodynamic changes in the 3 groups were evaluated after the treatment. Results Formation of CAS plaques was detected in monkeys in both MPQ and model groups. The vascular cross-sectional area, plaque cross-sectional area and stenosis rate of the plaques in the two groups all differed significantly from those in the blank control group(P<0.05),but these parameters were similar between MPQ group and the model group (P>0.05).Compared with those in the blank control group,the hemodynamic parameters showed significant changes in MPQ and the model groups (P<0.05) but remained similar between the latter two groups (P>0.05). Conclusion CAS plaques can cause changes in hemodynamic parameters.Short-term therapy with MPQ does not affect the stability of the plaques or cause adverse effects on hemodynamics in cynomolgus monkeys with mild CAS plaques.