| 动脉粥样硬化AR基因甲基化修饰的初步探讨 |
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| 引用本文： | 魏亚宁,舒青,张素珍.动脉粥样硬化AR基因甲基化修饰的初步探讨[J].第四军医大学学报,2004,25(15):1407-1409. |
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| 作者姓名： | 魏亚宁 舒青 张素珍 |
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| 作者单位： | 第四军医大学基础部医学遗传学与发育生物学教研室,陕西,西安,710033;第四军医大学基础部医学遗传学与发育生物学教研室,陕西,西安,710033;第四军医大学基础部医学遗传学与发育生物学教研室,陕西,西安,710033 |
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| 摘 要： | 目的:探讨雄激素受体(AR)基因CpG岛(CCGG)胞嘧啶甲基化模式与动脉粥样硬化(Atherosclerosis, AS)的关系. 方法:应用甲基化敏感的限制性内切酶及聚合酶链式反应(PCR)对96例动脉粥样硬化患者、91例正常对照人群AR基因CpG岛甲基化模式进行比较,并进行分析. 结果:男性患者AR基因CpG岛甲基化程度较男性对照组为低(P<0.05);女性患者AR基因CpG岛甲基化程度较女性对照组差异无显著(P>0.05);男性患者与女性患者相比较,男性患者AR基因CpG岛甲基化程度较低(P<0.05);男性对照与女性对照的甲基化模式差异无显著(P>0.05). 结论:AR基因CpG岛存在的低甲基化模式对AS诊断有一定的临床意义.
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| 关 键 词： | 动脉粥样硬化 雄激素受体基因 甲基化 |
| 文章编号： | 1000-2790(2004)15-1407-03 |
| 修稿时间： | 2004年3月31日 |
Study on methylation of AR gene in atherosclerosis |
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| Abstract: | AIM: To discuss the relationship between methylation of androgen receptor (AR) gene CpG island and atherosclerosis. METHODS: Hypersensitive methylation of restriction endonuclease and polymerase chain reaction were used to detect the methylation of AR gene CpG island in 96 atherosclerosis patients and ninety one control cases. RESULTS: The methylation in male patients was lower than that in male control ( P <0.05). The methylation had no obvious change between female patients and female control ( P >0.05). Male patients had lower methylation than that of female patients ( P <0.05) but there was no significant difference of methylation between male and female ( P >0.05). CONCLUSION: The dismethylation of AR gene CpG island may partly induce atherosclerosis. |
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| Keywords: | atherosclerosis androgen receptor gene methylation |
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