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| 万寿菊花中叶黄素及其酯体外淬灭单线态氧能力的比较 | |
| 引用本文： | 惠伯棣,裴凌鹏,李京,张艳.万寿菊花中叶黄素及其酯体外淬灭单线态氧能力的比较[J].中国药学杂志,2006,41(18):1385-1387. |
| 作者姓名： | 惠伯棣 裴凌鹏 李京 张艳 |
| 作者单位： | 1. 北京联合大学应用文理学院,北京,100083 2. 中国中医科学院,北京,100700 3. 首都师范大学生命科学院,北京,100037 |
| 摘 要： | 目的比较万寿菊花中叶黄素及其酯体外淬灭单线态氧能力。方法反相高效液相色谱(RP-HPLC)从万寿菊的花中制备叶黄素单体及酯两个组分。应用微弱发光检测技术测定和比较两者在体外淬灭单线态氧的能力。结果叶黄素单体和酯均具有体外淬灭单线态氧的能力,最小有效剂量分别为>0.1 g·L-1和>0.01 g·L-1。结论在研发以抗氧化功能为机制的药品时,应认真考虑应用叶黄素酯的可能性。 |
| 关 键 词： | 叶黄素 叶黄素酯 淬灭 单线态氧 |
| 文章编号： | 1001-2494（2006）18-1385-03 |
| 收稿时间： | 2005-04-07 |
| 修稿时间： | 2005-04-07 |
Comparison of Ability to Quench Singlet- Oxygen by Lutein and Its Esters from Marigold Flower in vitro |
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| HUI Bo-di,PEI Ling-Peng,LI Jing,ZHANG Yan.Comparison of Ability to Quench Singlet- Oxygen by Lutein and Its Esters from Marigold Flower in vitro[J].Chinese Pharmaceutical Journal,2006,41(18):1385-1387. | |
| Authors: | HUI Bo-di PEI Ling-Peng LI Jing ZHANG Yan |
| Institution: | 1.College of Applied Arts and Science，Beijing Union University，Beijing 100083，China；2.China Academy of Traditional Chinese Medicine，Beijing 100700，China；3. College of Life Science，Capital Normal University，Beijing 100037，China |
| Abstract: | OBJECTIVE To compare the ability to quench singlet-oxygen of lutein and its esters from marigold flower in vitro.METHODS Two fractions,free compound and esters of lutein were prepared by HPLC from the flower of marigold.The singlet-oxygen quenching ability by the fractions was determined with ultra weak luminescence analysis consequently.RESULTS All of the fractions,esters and free compound,extinguished singlet-oxygen in vitro,with the minimum amount of 0.01 g·L-1 and >0.1 g·L-1,respectively.CONCLUSION Those observations suggest that the application of esters,but not free compound,in pharmaceutical products with anti-oxidation function should be considered. |
| Keywords: | lutein lutein ester quenching singlet-oxygen |
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