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New circulating genomic variant of Crimean-Congo hemorrhagic fever virus in Iran |
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| Authors: | Sadegh Chinikar Nariman Shah-Hosseini Saeid Bouzari Tahmineh Jalali Mohammad Ali Shokrgozar Ehsan Mostafavi |
| Affiliation: | 1. Arboviruses and Viral Haemorrhagic Fevers Laboratory (National Ref. Lab), Pasteur Institute of Iran, Tehran, Iran 2. Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran 3. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran 4. Department of Epidemiology, Pasteur Institute of Iran, Tehran, Iran |
| Abstract: | Crimean-Congo hemorrhagic fever is a viral infection that is caused by Crimean-Congo hemorrhagic fever virus (CCHFV). On May 27, 2012, a woman became ill after accidentally splashing cow’s blood into her eyes. Serological and molecular investigations were carried out on the serum of the patient. The test results for serological testing were negative, but RT-PCR was strongly positive for CCHFV. A phylogenetic study on the CCHFV genome sequence showed 50 % similarity to a 520-bp region of Russian strains. By combining historical phylogenetic data and current data, it can be surmised that there are potentially more than five circulating CCHFV genomic variants in Iran. |
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