胃癌癌前病变的AgNOR定量研究

应用AgNOR染色技术对慢性表浅性胃炎(CSG)、慢性萎缩性胃炎(慢性萎缩性胃炎伴肠上皮生—CAG with IM及慢性萎缩性胃炎伴不典型增生CAG with Dys)和胃癌(GC)活检标本进行细胞核内AgNOR的定量研究。结果表明CSG组与CAG组、CAGwith IM组与GC组、CAGwith Dys组与GC组以及CAGwithIM组与CAGwithDys组细胞核内AgNOR均数比较都有极显著差异(P<0.01)。此外,各组AgNOR颗粒大小、位置和形态分布也不同,特别是CAGwith Dys组、CAGwith IM组合分别与GC组相比较,前者在AgNOR均数、大颗粒和不规则颗粒的百分比方面均比后者更接近于GC组数值,提示慢性萎缩性胃炎伴不典型增生与胃癌发生的关系更为密切。

QUANTITATIVE STUDY OF AgNOR IN PRECANCEROUS LESION OF GASTRIC CARCINOMA

The argyrophilic nucleolar organizer region associated protein (AgNOR) was investigated quantitaively in biopsy Specimens of chronic superficial gastritis, chronic atrophic gastritis, (chronic atrophic gastritis with intestinal metaplasia and chronic atrophic gastritis with dysplasia), and gastric carcinoma. It was found that the mean of AgNOR Was significantly different between any tWo of the above groups (p<0.01). There Were also some differences in size, site and shape of AgNOR among different groups, and especially When CAG with Dys and CAG with IM Werc compared respectivly with GC, the former group Was significantly closer to the numerical value of GC group in mean AgNOR number and in the percentage of greater and irregular granules, suggesting that CAG with Dys relates more closely to GC than CAG with IM