The value of combined use of survivin, cytokeratin 20 and mucin 7 mRNA for bladder cancer detection in voided urine |
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| Authors: | Xiao-Yong Pu Zhi-Ping Wang Yi-Rong Chen Xing-Huan Wang Yi-Long Wu Huai-Peng Wang |
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| Affiliation: | (1) Department of Urology, Guangdong Provincial People’s Hospital, Number 106, the 2nd Road of Zhongshan, Guangzhou, Guangdong, 510080, China;(2) The Cancer Research Center, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong, China;(3) The Medical Research Center, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong, China;(4) Department of of Urology, The Second Hospital, Lanzou University, Lanzhou, Gansu, China |
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| Abstract: | Objectives To evaluate the value of combined use of survivin, cytokeratin (CK) 20 and mucin (MUC) 7 mRNA in comparison with voided urine cytology in the detection of bladder cancer patients. Methods One hundred and fifty three patients and 20 healthy volunteers were evaluated by RT-PCR for detecting survivin, CK-20 and MUC7 mRNA in voided urine before cystoscopy. The three markers and cytology were evaluated independently or in combinations. Results The overall sensitivity and specificity were 90.4 and 94.7% for survivin, 82.6 and 97.4% for CK-20, 62.6 and 94.7% for MUC7 and 46.0 and 100% for voided urine cytology. Combined sensitivity of voided urine cytology with the three biomarkers together was higher than either combined sensitivity of voided urine cytology with one of the biomarkers or than that of the biomarker alone. Conclusions Combined use of the three markers can improve the sensitivity for detecting bladder cancer. |
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| Keywords: | Bladder cancer Tumor marker Survivin Cytokeratin 20 Mucin |
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