| Lymphocytes in patients with psoriasis promote proliferation of keratinocytes |
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| 引用本文： | 邓安梅 仲人前 等. Lymphocytes in patients with psoriasis promote proliferation of keratinocytes[J]. 中国人民解放军军医大学学报, 2002, 17(1): 51-53 |
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| 作者姓名： | 邓安梅 仲人前 等 |
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| 作者单位： | ClinicalImmunologyCenter,ChangzhengHospital,SecondMilitaryMedicalUniversity,Shanghai200003,China |
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| 基金项目： | Supported by the National Natural Science Foundation of China (No. 39970684) |
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| 摘 要： | Objective: To analyze the effect of lymphocytes on proliferation of keratinocytes in patients with psoriasis. Methods: Lymphocytes in lesion and peripheral blood were isolated and amplified, then cultured together with normal keratinocytes. By MTT method, the living cells were quantified in the mixed culture. Results: Compared with normal controls, lymphocytes from lesion and peripheral blood of psoriasis both promote the proliferation of keratinocytes (P<0. 01 and P<0. 05 respectively). The concentrations of IL-2 and IFN-7 in the mixture of lesion lymphocytes and keratinocytes were significantly higher than that of controls. Tripterygium glycosides inhibited this promotion. Conclusion: Lymphocytes in patients with psoriasis (mainly Th1 cell) play an important role in proliferation of keratinocytes. This psoriasis cell model is useful for studies on signal transduction in psoriasis.
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| 关 键 词： | 牛皮癣 淋巴细胞 角质化细胞 细胞增殖 |
Lymphocytes in patients with psoriasis promote proliferation of keratinocytes |
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| DENG An-Mei,ZHONG Ren-Qian,CHEN Sun-xiao,ZHOU Ye,KONG Xian-Tao. Lymphocytes in patients with psoriasis promote proliferation of keratinocytes[J]. Journal of Medical Colleges of PLA(China), 2002, 17(1): 51-53 |
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| Authors: | DENG An-Mei ZHONG Ren-Qian CHEN Sun-xiao ZHOU Ye KONG Xian-Tao |
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| Abstract: | Objective: To analyze the effect of lymphocytes on proliferation of keratinocytes in patients with psoriasis. Methods: Lymphocytes in lesion and peripheral blood were isolated and amplified, then cultured together with normal keratinocytes. By MTT method, the living cells were quantified in the mixed culture. Results: Compared with normal controls, lymphocytes from lesion and peripheral blood of psoriasis both promote the proliferation of keratinocytes (P<0. 01 and P<0. 05 respectively). The concentrations of IL-2 and IFN-7 in the mixture of lesion lymphocytes and keratinocytes were significantly higher than that of controls. Tripterygium glycosides inhibited this promotion. Conclusion: Lymphocytes in patients with psoriasis (mainly Th1 cell) play an important role in proliferation of keratinocytes. This psoriasis cell model is useful for studies on signal transduction in psoriasis. |
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| Keywords: | psoriasis lymphocyte keratinocyte |
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