Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm |
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Authors: | Chen Zheng W Letvin Norman L |
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Affiliation: | Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113/RE216, Boston, MA 02115, USA. zchen@caregroup.harvard.edu |
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Abstract: | The role of gammadelta T cells in adaptive immunity remains uncertain. Recent studies have demonstrated that a unique subset of gammadelta T cells in primates can mount adaptive immune responses during mycobacterial infections. This Review discusses notable similarities and differences in adaptive immune responses between non-peptide-specific gammadelta T cells and peptide-specific alphabeta T cells, and discusses both the molecular basis for gammadelta T-cell responses and potential functions of these enigmatic cells. |
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