1307例药品不良反应的医院质控负性指标监控分析

目的 分析某三甲医院2012-2015年发生的药品不良反应(adverse drug reactions,ADR)的特点和规律,为临床合理用药提供依据.方法 根据患者性别、年龄、药品种类、给药途径、累及的器官或系统、临床表现及上报人职业等,对该院1307例ADR包括进行统计和分析.结果 1307例ADR报告中,男性的发生比例高于女性,61~70岁的老年人占26.55%;ADR药品种类以抗肿瘤药最多(45.44%),其次是抗感染药物(20.95%);给药途径以静脉给药最多(73.22%);ADR累及器官或系统以消化系统损害为主.预后分析,95.8%的ADR患者痊愈或好转.结论 临床上应深入加强ADR的监测与报告,规范抗肿瘤药物的使用,合理使用抗菌药,减少ADR的发生,保障患者用药安全.

Monitorin analysis of negative index of hospital quality control based on 1307 cases of adverse drug reaction reports

Objective To provide the references for clinical rational drug use by analyzing the characteristics and distribution of adverse drug reaction( ADR) from a 3A grade hospital in 2012 to 2015. Methods 1307 cases of effective ADR in our hospital were analyzed statistically in respect of patients' sex and age, route of administration, category of drugs, organs or systems, and clinical manifestation, occupation of reporting people involved etc in ADR. Results Among 1307 cases of ADR, the percentage of ADR in male was higher than that in female, and the rate of ADR was highest in 61 to 70 years old group( 26. 55%) . In the classification of the drugs, the most ADR cases was caused by antitumor drugs (45. 44%), followed by anti infective drugs (20. 95%). The route of intra-venous administration was the most ( 73. 22%) . The main clinical manifestation of ADR was digestive system damage. 95. 8% patients with ADR have a good prognosis. Conclusion In order to ensure patients safety, hospital should pay more attention to report and monitor of ADR in clinic. Antitumor and anti-infective drugs should be rationally used so as to reduce the incidence of ADR and ensure patients safety.