Transformation of rat tracheal epithelial cells by benzo[a]pyrene and its metabolites |
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Authors: | Vernon E Steele Ann C Marchok Gerald M Cohen |
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Institution: | Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37830 U.S.A. |
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Abstract: | Benzoa]pyrene (Ba]P) and its 7,8-dihydrodiol form were metabolically activated to malignantly transform a non-tumorigenic rat tracheal epithelial cell line in culture. The proximal carcinogenic metabolite of Ba]P, diolepoxide I, was more efficient in transforming the epithelial cell line than the intermediate or parent compound, even at a 50- or 100-fold lower concentration, respectively. Inoculations of the transformed cell lines into immunosuppressed isogenic recipients produced differentiated carcinomas similar to those which occur in humans. |
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Keywords: | To whom reprint requests should be addressed |
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