Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis |
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Authors: | Samsonov MY; Nassonov EL; Tilz GP; Geht BM; Demel U; Gurkina GT; Shtutman VZ; Guseva AG; Wachter H; Fuchs D |
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Institution: | Cardiology Research Centre, Moscow, Russia. |
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Abstract: | We determined serum concentrations of neopterin, soluble tumour necrosis
factor (55 kDa) receptor (sTNF-R) and soluble interleukin-2 receptor
(sIL-2R) in plasma of 44 patients with polymyositis (PM)/dermatomyositis
(DM), including 15 patients with primary PM, 13 patients with primary DM,
and 16 patients with myositis and systemic sclerosis in overlap.
Concentrations of neopterin, sTNF-R and sIL-2R were measured using
commercially available immunoassays. Serum neopterin was increased in 35 of
44 PM/DM patients (80%), sTNF-R in 14 (32%) and sIL-2R in 18 (41%)
patients, respectively. There were significant correlations between serum
neopterin and sTNF-R, sIL-2R and erythrocyte sedimentation rate (all P <
0.001). Neopterin, as well as sTNF-R and sIL-2R, did not correlate with
clinical (neuromuscular and activities of daily living scores) and
laboratory (creatine kinase levels) manifestations of myositis. Increased
serum levels of neopterin were associated with non-muscular manifestations
of PM/DM. In conclusion, serum neopterin appears to be a useful laboratory
marker for ongoing immune activation and global disease activity in PM/DM.
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