| 维拉帕米、硝苯啶和粉防己碱加强吲哚美辛的镇痛作用 |
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| 引用本文： | 黄国平 马传庚. 维拉帕米、硝苯啶和粉防己碱加强吲哚美辛的镇痛作用[J]. 中国药理学通报, 1993, 9(1): 36-39 |
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| 作者姓名： | 黄国平 马传庚 |
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| 作者单位： | 安徽医科大学药理教研室，安徽医科大学药理教研室，安徽医科大学药理教研室 合肥230032 江西省药品检验所，南昌 330046，合肥230032，合肥230032 |
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| 摘 要： | 研究维拉帕米(Ver)、硝苯啶(Nif)粉防已碱(Tet)对吲哚美辛(Ind)镇痛作用的影响。用冰醋酸和MgSO_4分别致小鼠扭体模型.Ind、Nif、ver及Tet都表现镇痛作用。在MgSO_4 致扭体模型上除Ver外,Nif、Tet分别与Ind合用均可显著提高镇痛效应。小鼠热板模型,10mg·kg~(-1)Jnd无镇痛作用,但和Ver合用.其镇痛作用显著加强。在小鼠甩尾模型上,10mg·kg~(-1)Ind及20、40 mg·kg~(-1)的Nif均无显著的镇痛效应.但二者分别合用,其镇痛作用都很显著。在小鼠热板和甩尾模型上,icv Ver、Nif、Tet均有显著的镇痛作用,提示Vet、Nif、Tet的镇痛作用可能有中枢机制参与。
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| 关 键 词： | 吲哚美辛 硝苯啶 粉防己碱 吲哚美辛 镇痛作用 加强作用 |
The anaigesic effects of indomethacin are strengthed with verapamil,nifedipine and tetrandrine |
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| HUANG Guo-Ping,MA Chuan-Geng.XU Shu-Yun. The anaigesic effects of indomethacin are strengthed with verapamil,nifedipine and tetrandrine[J]. Chinese Pharmacological Bulletin, 1993, 9(1): 36-39 |
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| Authors: | HUANG Guo-Ping MA Chuan-Geng.XU Shu-Yun |
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| Affiliation: | HUANG Guo-Ping1,MA Chuan-Geng.XU Shu-Yun |
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| Abstract: | The co-telationships of analgesic effects between veraparnil (Ver ) , nifedipine (Nif) , tetrandrine (Tet)and indomethacin (Ind) respectively (resp) were studied in this paper. Ind,Ver,Nif and Tet were against acetic acid -induced or MgSO4 - induced writhing in mice . Ind + Nif, Ind + Tet showed more potent analgesic effects than that of these drugs were used alone resp. In the hot -plate test in mice 10 mg· kg-1Ind failed to show analgesic effect,but 10mg·kg-1Ind+10 mg·kg-1Ver showed analgesic actively. In the tail - flick test in mice, nither Nif 20,40 mg·kg-1nor Ind 10 mg·kg-1showed the analgesic effects. Nif 20,40 mg·kg-1+Ind 10 mg·kg-1showed analgesic effect. In the hot - plate and tail -flick test in mice, icv. Ver ,Nif, Tet showed analgesic effects It suggests that central mechnism might take part in the anaige-sia of Ver,Nif and Tet. |
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| Keywords: | verapamil nifedipines te-trandtine indomethacin analgesia potentiation |
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