| IHC-72抗大鼠缺血再灌注心律失常及脂质过氧化作用 |
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| 引用本文： | 姬广聚 张敬珍. IHC-72抗大鼠缺血再灌注心律失常及脂质过氧化作用[J]. 中国药理学通报, 1993, 9(2): 129-131 |
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| 作者姓名： | 姬广聚 张敬珍 |
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| 作者单位： | 总后医学专科学校药理教研室 北京100071(姬广聚，张敬珍)，第四军医大学药理教研室 西安710032(赵德化，刘德强)，第四军医大学药理教研室 西安710032(盛宝恒) |
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| 摘 要： | 在大鼠整体模型上,观察了IHC-72对缺血再灌注心律失常及脂质过氧化作用的影响.缺血1h、再灌注30min,出现明显的心律失常,血浆谷草转氨酶(GOT)、乳酸脱氢酶(LDH)及游离脂肪酸(FFA)释放明显增加;心肌组织超氧化物歧化酶(SOD)活性显著降低、丙二醛(MDA)含量增加。IHC-725mg·kg~(-1)明显降低室早、室速及室颤发生率,缩短室速及室颤持续时间;显著减少GOT、LDH和FFA的释放,保护SOD活性、减少MDA生成。结果提示:IHC-72具有抗缺血再灌注心律失常及抗脂质过氧化作用。
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| 关 键 词： | IHC-72 维拉帕米 心肌缺血再灌注损伤 心律失常 脂质过氧化 |
The effects of IHC-72 on arrhythmia and lipid peroxides of ischemia and reperfusion rat hearts in vivo |
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| JI Guang-Ju,ZHANG Jing-Zhen,ZHAO De-Hua. The effects of IHC-72 on arrhythmia and lipid peroxides of ischemia and reperfusion rat hearts in vivo[J]. Chinese Pharmacological Bulletin, 1993, 9(2): 129-131 |
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| Authors: | JI Guang-Ju ZHANG Jing-Zhen ZHAO De-Hua |
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| Abstract: | Acute myocardial ischemia and reperfusion led to arrhythmias and increase of glutamic oxalacetic transaminase (GOT),lactate dehydrogenase (LDH),non-csterified fatty acid (FFA) and malondialdehyde (MDA) content, and decrease of superoxide dismutase (SOD) activity in rats. 3, 6-di-methylamino-dibenzopyri-odonium edetate (IHC-72) 5 mg·kg-1 iv significantly reduced the incidence of ventricular tachy-cardia (VT) and ventricular fibrillation(VF) ,shortened the duration of arrhythmias induced by reperfusion, decreased the release of GOT, LDH and FFA, obviously reduced the MDA content,and effectively protected SOD activity in ischemia-reperfused rat hearts. Our experimental results suggested that IHC-72 had protective effects on ischemia-reperfusion injury rat hearts in vivo. The mechanism of the protection might be associated with the inhibition of cellular lipid peroxidation. |
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| Keywords: | IHC-72 verapamil myocardial reperfusion in jury arrhythmia lipid peroxides |
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