糖皮质激素鼻喷雾剂对儿童肾上腺皮质功能的影响

目的:探讨应用糖皮质激素对变应性鼻炎儿童皮质醇、生长激素(GH)及身高的影响。方法:变应性鼻炎患儿25例(观察组)给予布地奈德鼻喷雾剂治疗,每鼻孔1掀,2次/d,疗程4周。同时口服氯雷他定糖浆,用药剂量为0.11～0.24mg/kg,1次/d,用药4周。治疗前和治疗后6个月采静脉血5ml,采用放射免疫分析法(RIA)测定其血清皮质醇、生长激素(GH)水平,应用标准法测量并记录观察组及对照组身高。结果:观察组儿童用药前及用药6个月后其血清皮质醇和GH水平均无显著性差异。观察组身高治疗前、治疗后6个月时与对照组儿童身高比较无显著性差异。结论:糖皮质激素对变应性鼻炎儿童血清皮质醇和GH及身高的生长发育无明显影响。

Influence of corticosteroids on system of cortisol-growth hormone in children withAllergic rhinitis

Objective:To explore the changes of cortisol-growth hormone before and after corticosteroids in children with allergic rhinitis and to observe the variation of height between sick children and healthy children.Methods: Twenty-five children with allergic rhinitis were collected as observation group,and the patients were received budesonide one spray per nostril,two times per day for 4 weeks.Meanwhile these children took orally loratadine syrup for 4 weeks.The serum blood were collected before treatment and after treatment 6 months;the contents of cortisol and growth hormone(GH) were measured by radio immunoassay(RIA).The height was measured and recorded by standard method.Results: The levels of serum cortisol and GH in children with allergic rhinitis had no significant differences before and after 6 months therapy.The height of children in observation group and control group which were healthy and had the same age and gender had no significant differences before therapy and after 6 months therapy.Conclusions: The serum consentbations of cortisol and GH in children suffered from allergis rhinitis have no obvious change before and after 6 months budesonide spray.The height changes before and after therapy have no significant difference between observation group and control group.