心痛方治疗不稳定性心绞痛临床疗效及对血清基质金属蛋白酶2的影响

目的观察心痛方治疗不稳定性心绞痛(UAP)痰瘀气滞痹阻证患者的临床疗效及对血清基质金属蛋白2(MMP-2)的影响,探讨其治疗UAP的机制。方法采取随机分层法,将符合纳入标准的患者随机分为治疗组30例(心痛方+西医常规治疗)及对照组30例(西医常规治疗),均连续用药4周,进行临床疗效观察并检测2组治疗前后血清MMP-2水平变化。结果治疗组在改善中医证候、缓解心绞痛、停减硝酸甘油使用以及降低血清MMP-2浓度等方面均明显优于对照组。结论心痛方治疗UAP有良好疗效,能降低UAP患者血清MMP-2水平,从而减缓粥样斑块的进展,稳定斑块。

Clinical Curative Effect of Xintong Decoction on Patients with Unstable Angina Pectoris and Impact on Serum Matrix Metalloproteinase 2

Objective To observe the clinical curative effect of Xintong decoction in treating unstable angina pectoris （UAP） and impact on serum matrix metalloproteinase 2 （MMP-2） of patients with syndrome of phlegm and blood stasis, qi stagnation and obstruction of heart meridian, and probes into its intervention mechanism on UAP. Method Patients were randomly divided into treatment group （30 cases, treated with Xiaotong decoction ＋ routine western medicine） and control group （30 cases, treated with routine western medicine）. The course was four weeks. The clinical curative effect was observed and serum MMP-2 before and after treatment was detected. Results TCM syndrome score, angina pectoris, nitroglycerin discontinue rate, serum concentration of MMP-2 in the treatment group were significantly better than the control group. Conclusion Xintong decoction has good curative effect in treating UAP. It can reduce the serum level of MMP-2 of patients with UAP, so as to slowing the progress of plaque and stabilizing plaques.