成人乙肝疫苗免疫失败危险因素配对病例对照研究

目的：探讨成人乙肝疫苗免疫失败的危险因素，为采取干预措施提供依据。方法：采用配对病例对照研究方法，对330对病例和对照进行问卷调查，应用SPSS13．0软件进行统计分析。结果：共全程接种4273人，免疫失败率为8．3％，单因素分析显示：体重指数（BMI）、吸烟、饮酒、乙肝家族史与免疫失败有统计学关联（P〈0．01），多因素分析显示：吸烟、肥胖、有乙肝家族史是乙肝疫苗免疫失败发生的危险因素，OR值分别是1．029-2．722、3．198-25．760和3．999～35．820。结论：控制体重、禁烟、预防家庭内交叉感染可促进免疫成功。

A matched case-control study of risk factors on invalid immunization of hepatitis B vaccination in adults

Objective To investigate the risk factors of invalid immunization of hepatitis 13 vaccination on adults and to provide intervening strategies. Methods Pair matched case- control study method was used. 330 cases and 330 controls were interviewed by questionnaires. Statistical analyses were performed by using SPSS software. Results 4, 273 adults were vaccinated and the rate of invalid anti--HBs was 8.3%. Factors such as BMI,smoking,drinking, family history were associated with invalid immunization risk in one--way variance model ,and multiple factor logistic regression showed that 3 factors such as smoking,BMI,family history were associated with invalid immunization,with OR value of 1. 029 - 2. 722, 3. 198 - 25. 760 and 3. 999 - 35. 820 respectively. Conclusion The rate of invalid immunization could be reduced by keeping natural BMI, forbidding smoking and preventing cross infection in the family.