|
|||||
|
|
Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescencein situ hybridization |
|
| Authors: | Kiyoshi Inoue Johji Inazawa Hitoshi Nakagawa Tsutomu Shimada Hiroshi Yamazaki F. Peter Guengerich Tatsuo Abe |
| Affiliation: | (1) Osaka Prefectural Institute of Public Health, Nakamichi, Higashinari-ku, 537 Osaka, Japan;(2) Department of Hygiene, Kyoto Prefectural University of Medicine, Kamigyo-ku, 602 Kyoto, Japan;(3) Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, 602 Kyoto, Japan;(4) Department of Biochemistry and Center in Molecular Toxicology, 37232 Nashville, Vanderbilt University School of Medicine, TN, U.S.A. |
| Abstract: | Summary We have used a full length cDNA clone (2.2 kb) for the human cytochrome P-450 nifedipine oxidase (CYP3A4) enzyme as a probe to determine its chromosome localization by fluorescencein situ hybridization. CYP3A4 was mapped on R-banded human prometaphase chromosomes, and the precise localization of CYP3A4 on chromosome 7 was further confirmed by a delineation of G-banded pattern on the same prometaphase chromosomes through a combination of UV-filter. We assigned CYP3A4 to chromosome 7 at q22.1. |
| Keywords: | fluorescencein situ hybridization CYP3A4 chromosomal mapping chromosome 7 |
| 本文献已被 SpringerLink 等数据库收录！ | |