The development of retinopathy in sucrose-fed and streptozotocin-diabetic rats |
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Authors: | D. Papachristodoulou H. Heath S. S. Kang |
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Affiliation: | (1) Department of Biochemical Pathology, University College Hospital Medical School, London, England;(2) Present address: Dept. of Physiologie, Queen Elizabeth College, London, England |
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Abstract: | Summary Normal and streptozotocin-diabetic rats have been maintained for 6–11 months on completely balanced, reconstituted diets in which the sole source of carbohydrate was either 68% corn starch or 68% sucrose. The retinal vascular system was isolated by trypsin digestion and examined histologically for the presence of tortuosity and irregularity of capillary diameter, increased PAS-positive deposits, microaneurysms, loss of pericytes, endothelial proliferation, acellularity and strand formation. None of these pathological changes occurred in normal rats fed a starch-rich diet, but all developed to a similar extent in the sucrose-fed normal rats and the starch-fed diabetic group. The changes were more severe in sucrose-fed diabetic rats after 6 months. In all groups the retinopathy progressed with time. The possibility that a factor common to both the ingestion of a sucrose-rich diet and streptozotocin diabetes in rats has been considered since, histologically, the retinopathy observed was identical both with respect to severity and rate of development in normoglycaemic, sucrose-fed and hyperglycaemic, starch-fed diabetic rats. |
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Keywords: | Sucrose-diet streptozotocin-diabetes retinopathy rats trypsin digests |
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