| 心肌缺血及再灌注后心肌钙调蛋白及环磷酸腺苷含量的变化 |
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| 引用本文： | 邢虹,王孝铭,张国义,刘景生.心肌缺血及再灌注后心肌钙调蛋白及环磷酸腺苷含量的变化[J].中国病理生理杂志,1991(1). |
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| 作者姓名： | 邢虹 王孝铭 张国义 刘景生 |
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| 作者单位： | 哈尔滨医科大学病理生理学教研室
(邢虹，王孝铭，张国义)，中国医学科学院基础所药理室(刘景生) |
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| 摘 要： | 本文应用放免技术对家兔心肌急性缺血及再灌注后心肌组织钙调蛋白(CaM)和环磷酸腺苷(cAMP)的变化进行了初步观察。缺血20分钟时,心肌组织CaM和cAMP含量均升高,缺血40分钟时,二者与缺血20分钟时比无明显变化。缺血20分钟时再灌注,心肌组织CaM含量下降,cAMP含量上升,缺血40分钟时再灌注与缺血20分钟再灌注相比CaM含量升高,cAMP含量下降。文章讨论了这些变化的可能机制。
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| 关 键 词： | 钙调素 腺苷环一磷酸 心脏 |
The changes of calmodulin and cAMP in rabbit myocardium during ischemia and reperfusion |
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| Xing Hong,Wang Xiao-Ming,et al.The changes of calmodulin and cAMP in rabbit myocardium during ischemia and reperfusion[J].Chinese Journal of Pathophysiology,1991(1). |
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| Authors: | Xing Hong Wang Xiao-Ming |
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| Institution: | Xing Hong,Wang Xiao-Ming,et al Department of Pathophysiology Harbin Medical University,Harbin |
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| Abstract: | This study was performed on rabbits to examine the changes of calmodulin (CAM) and cAMP in the myocardium during ischemia and reperfusion by radioimmunoassay method. The result showed the levels of CaM and cAMP increased at 20 min of ischemia. Although these two parmeters were unchanged at 40 min of ischemia as compared with the changes at 20 min, they were changed during reperfusion at different times of ischemia. At 20 min ischemia following 10 min reperfusion, the content of CaM decreased, the content of cAMP increased. On the basis of 40 min ischemia, reperfusion induced opposite changes: CaM increased, cAMP decreased. The possible mechanism of these changes was discussed. |
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| Keywords: | Calmodulin Adenosine cyclic monophosphate Heart |
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