糖链抗原50和242对结直肠癌诊断的价值

目的探讨糖链抗原50(CA50)和242(CA242)在结直肠癌诊断中的应用价值。方法应用放免法测定71例结直肠癌患者和48例结直肠良性疾病患者血清中CA50、CA242的水平并进行统计学处理。结果CA50在结直肠良性疾病和结直肠癌中的阳性率分别6.3%和69.0%,CA242的分别为8.3%和73.2%,二者在良恶性病变中的水平均有显著性差异(P<0.001);CA50在结直肠癌未发生转移组和已发生转移组的阳性率分别为52.8%和82.8%,CA242的分别为44.4%和88.6%,二者在未发生和已发生转移组中的水平亦均有显著性差异(P<0.01)。结论CA50和CA242的血清水平在结直肠癌中比结直肠良性疾病中为高,在结直肠癌的晚期比早期为高,对结直肠癌的临床诊断具有一定价值,可和其他血清肿瘤标记物联合检测,互相弥补以提高检出率;也可通过动态观察其血清水平,推测患者病情的进展。

Clinical value of carbohydrate antigen 50 and carbohydrate antigen 242 in the diagnosis of colorectal carcinoma

Objective Carbohydrate antigen 50 (CA50) and 242 (CA242), recently recognized as serum tumor markers, are studied for their value in the diagnosis of the colorectal carcinoma. Methods This study included 48 patients with benign bowel disease and 71 patients with colorectal carcinoma, whose serum CA50 and CA242 levels were measured by immunoradiometric assay. Results The total positivity of CA50 and CA242 in colorectal carcinoma cases were 69.0% and 73.2% respectively, and were only 6.3% and 8.3% in benign cases. In non-metastatic colorectal carcinoma cases, the positivity rates for CA50 and CA242 were 52.8% and 44.4% respectively, which were 82.8% and 88.6% in cases with metastasis. Marked elevation in CA242 level was noted in the patients with colon carcinoma (77.5%). But at early stage of the malignancy, both tumor markers had low sensitivity. Conclusions CA50 and CA242 are valuable tumor markes in the diagnosis of colorectal carcinoma.