紫杉醇加氟尿嘧啶持续静脉滴注治疗晚期胃癌

目的观察紫杉醇联合醛氢叶酸和氟尿嘧啶持续静脉滴注治疗晚期胃癌的疗效和毒副反应。方法经病理组织学诊断的晚期胃癌26例，紫杉醇(paclitaxel，PTX，商品名为泰素Taxol)135mg／m^2，静脉滴注3h，第1天；醛氢叶酸(leucovorin，LV)200mg／m^2，静脉滴注2h，随后5-氟尿嘧啶(5-Fluorouracil，5-Fu)375mg／m^2，静脉推注10min，再接5-Fu3．0g／m^2用输液泵连续滴注120h，21d为1周期。所有患者至少接受2个周期治疗。结果26例均可评价疗效，总有效率为46．2％，其中CR2例，占7．7％。主要毒副反应为骨髓抑制、恶心呕吐、腹泻、黏膜炎、脱发、关节肌肉痛和心脏毒性反应，但均可耐受。结论PTX联合LV和5-Fu持续静脉滴注治疗晚期胃癌疗效较好，毒性可以耐受。

Paclitaxel combined with 5-Fluorouracil continuous infusion for treatment of advanced gastric cancer

Objective To observe the efficacy and toxicity of paclitaxel combined with leucovorin/5- fluorouracil continuous infusion in patients with advanced gastric cancer. Methods 26 patients with a histologic diagnosis of advanced gastric cancer were observed. The chemotherapy regimen comprised of PTX 135 mg/m2 infusion for 3 hours, LV 200 mg/m2 infusion for 2 hours followed by 10 minutes intravenous infusion of 5- Fu 375 mg/m2, then 120 hours infusion of 5- Fu 3.0 g/m2 with an ambulatory pump, repeated every 3 weeks. All patients were received at least two cycles of treatment. Results All the cases could be evaluated. The total response rate was 46.2 %. Two obtained complete remission (CR) (7.7 %). The major toxic side effects were neutropenia, nausea, vomiting, mucositis, alopecia, arthralgia, myalgia and cardiac toxic reaction, but were tolerable. Conclusions The combination of paclitaxel and 5- Fu continuous infusion is an effective and tolerable regimen in the treatment of gastric cancer.