Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies |
| |
Authors: | Yoichiro Takata Hiroshi Inoue Aya Sato Kazue Tsugawa Katsutoshi Miyatake Daisuke Hamada Fumio Shinomiya Shunji Nakano Natsuo Yasui Toshihito Tanahashi Mitsuo Itakura |
| |
Institution: | (1) Division of Genetic Information, Institute for Genome Research, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima Tokushima, 770-8503, Japan;(2) Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima, Tokushima, Japan |
| |
Abstract: | We conducted population-based association tests for the four selected SNPs (rs2240340/padi4_94, rs7528684/fcrl3_3, rs3792876/slc2F2 and rs2268277/runx1) previously reported to be associated with rheumatoid arthritis (RA). The study population consisted of 950 unrelated Japanese
subjects with RA and 507 controls, none of whom had previously been tested for these variants. Only the SNP rs2240340/padi4_94 was modestly associated with RA allele odds ratio (OR) 1.22, 95% confidence interval (CI) 1.04–1.43, P = 0.012]. The most significant association effect was found for genotype contrast between minor and major allele homozygotes
(OR 1.53, 95% CI 1.10–2.12, P = 0.010). No other SNPs showed a statistically significant association with RA in our population. Meta-analysis of published
studies and our new data confirmed a highly significant association between PADI4 gene SNPs and increased risk of RA in East Asian populations (allele fixed-effects summary OR 1.31, 95% CI 1.22–1.41, P < 0.0001). We found some evidence for an association of either rs7528684/fcrl3_3 or rs3792876/slc2F2 with RA; however, because the magnitudes of effects were apparently much weaker than those reported in the initial positive
reports, and there were substantial levels of inter-study OR heterogeneity, we concluded that additional studies are needed
to fully understand the present results.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
| |
Keywords: | Rheumatoid arthritis PADI4 FCRL3 SLC22A4 RUNX1 Single nucleotide polymorphisms Genetic association study Meta-analysis |
本文献已被 PubMed SpringerLink 等数据库收录! |
|