| 胚胎期和生长期子代大鼠砷暴露对脑细胞线粒体功能和超微结构的影响 |
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| 引用本文： | 朱筑霞,吴泽江,王旭东,易必达,潘玮炜. 胚胎期和生长期子代大鼠砷暴露对脑细胞线粒体功能和超微结构的影响[J]. 环境与健康杂志, 2011, 28(6): 488-490 |
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| 作者姓名： | 朱筑霞 吴泽江 王旭东 易必达 潘玮炜 |
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| 作者单位： | 贵阳医学院生理学教研室,贵州贵阳,550004 |
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| 基金项目： | 贵州省科技厅科技攻关项目[2002,1123)] |
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| 摘 要： | 目的 观察胚胎期和生长期连续砷暴露的仔鼠脑神经细胞线粒体功能和超微结构的变化,探讨砷对子代大鼠脑功能损伤机制.方法 SD大鼠随机分成对照组、低、高砷染毒组,染砷组自由饮用As2O3水溶液,剂量为0.6、15 mg/kg,6周后,各组分别雄雌2∶1合笼产仔,仔鼠由各自染砷母代乳养至断乳后,仔鼠离开母鼠继续本组剂量染砷到6...
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| 关 键 词： | 砷 脑细胞 线粒体 呼吸功能 超微结构 大鼠 |
Change of Brain Cellular Mitochondrial Function and Ultrastructure in Offspring Rats Exposed to Arsenic during Gestation and Growth |
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| ZHU Zhu-xia,WU Ze-jiang,WANG Xu-dong,et al.. Change of Brain Cellular Mitochondrial Function and Ultrastructure in Offspring Rats Exposed to Arsenic during Gestation and Growth[J]. Journal of Environment and Health, 2011, 28(6): 488-490 |
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| Authors: | ZHU Zhu-xia WU Ze-jiang WANG Xu-dong et al. |
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| Affiliation: | ZHU Zhu-xia,WU Ze-jiang,WANG Xu-dong,et al.Department of Physiology,Guiyang Medical College,Guiyang,Guizhou 550004,China |
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| Abstract: | Objective To investigate the toxic effects of arsenic on brain nerve cellular mitochondrial function and ultrastructure of F1 generation rats exposed to arsenic during gestation and growth.Methods Sprague-Dawley(SD) rats of cleanliness grade were randomly divided into three group(low-,high-dose arsenic group and control group),treated with arsenic(As2O3) at doses of 10 mg/kg,0.4 mg/kg,the control group with distilled water,for 6 consecutive weeks.F1 pup rats were lactated by dam exposed arsenic until weanin... |
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| Keywords: | Arsenic Brain cell Mitochondrion Respiratory function Ultrastructure Rat |
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