| 氯化镧对大鼠大脑皮质即早基因表达的影响 |
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| 引用本文： | 杨敬华,刘秋芳,巫生文,蔡原. 氯化镧对大鼠大脑皮质即早基因表达的影响[J]. 环境与健康杂志, 2011, 28(6): 471-474 |
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| 作者姓名： | 杨敬华 刘秋芳 巫生文 蔡原 |
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| 作者单位： | 中国医科大学公共卫生学院卫生毒理学教研室,辽宁沈阳,110001 |
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| 基金项目： | 国家自然科学基金(30800925) |
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| 摘 要： | 目的 研究大鼠生长发育期氯化镧(lanthanum chloride,LaCl3)暴露对大鼠大脑学习记忆能力和皮质即刻早期基因c-jun、egr1和Arc表达的影响.方法 将40只Wistar孕鼠随机分为饮用0.25%、0.5%、1.0%LaCl3蒸馏水溶液的3个染毒组和饮用蒸馏水的对照组.染毒组仔鼠断乳后继续分别自行...
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| 关 键 词： | 氯化镧 大脑皮质 c-jun基因 egr1基因 |
Effect of Lanthanum Chloride on Expression of Immediate Early Genes in Cerebral Cortex of Rats |
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| YANG Jing-hua,LIU Qiu-fang,WU Sheng-wen,et al.. Effect of Lanthanum Chloride on Expression of Immediate Early Genes in Cerebral Cortex of Rats[J]. Journal of Environment and Health, 2011, 28(6): 471-474 |
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| Authors: | YANG Jing-hua LIU Qiu-fang WU Sheng-wen et al. |
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| Affiliation: | YANG Jing-hua,LIU Qiu-fang,WU Sheng-wen,et al.Department of Toxicology,College of Public Health,China Medical University,Shenyang,Liaoning 110001,China |
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| Abstract: | Objective To study the effects of lanthanum chloride(LaCl3) on the ability of learning and memory and immediate early genes including c-jun,egr1 and Arc expression in the cerebral cortex of rats during growth and development period.Methods Forty Wistar pregnant rats were randomly divided into three groups treated with LaCl3 at 0.25%,0.5% and 1.0% LaCl3 through drinking water and control group drinking distilled water.After weaning,the pups in LaCl3 groups continued to be treated with LaCl3 at 0.25%,0.5% and... |
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| Keywords: | Lanthanum chloride Cerebral cortex c-jun gene egr1 gene |
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