| 二甲双胍对初发2型糖尿病患者同型半胱氨酸和颈动脉内膜厚度的影响 |
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| 引用本文： | 米念荣,孟超,王淑芳.二甲双胍对初发2型糖尿病患者同型半胱氨酸和颈动脉内膜厚度的影响[J].山东大学学报(医学版),2011,49(7):6-8,14. |
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| 作者姓名： | 米念荣 孟超 王淑芳 |
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| 作者单位： | 山东大学 1.医学院, 济南 250012; 2.附属济南市中心医院内分泌科, 济南 250013 |
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| 摘 要： | 目的 观察初发2型糖尿病患者(T2DM)二甲双胍治疗前后血浆同型半胱氨酸( Hcy)、颈动脉内膜中层厚度(IMT)的变化及其二者之间的关系。方法 选择30例初发T2DM患者(T2DM组)与20例健康志愿者(正常对照组)，比较两组Hcy和IMT的差异。T2DM组患者在合理膳食和适当运动的同时加服二甲双胍1500mg/d,疗程为1年, 检测治疗前后Hcy和IMT的变化，利用多元线性回归分析二者之间变化关系。结果 与正常对照组相比，T2DM组血浆Hcy浓度和IMT显著增高(P<0.01，P<0.05)，经二甲双胍治疗后,血浆Hcy浓度和IMT均显著降低(P均<0.05)，且IMT与血浆Hcy浓度呈正相关(P<0.01)。结论 血浆Hcy和IMT在预测T2DM大血管并发症方面有重要的临床意义，对初发T2DM早期应用二甲双胍能延缓其大血管并发症的发生发展。
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| 关 键 词： | 二甲双胍 2型糖尿病 同型半胱氨酸 颈动脉内膜中层厚度 |
| 收稿时间： | 2011-01-18 |
The influence of metformin on HCY and IMT in newly diagnosed type 2 diabetes |
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| MI Nian-rong,MENG Chao,WANG Shu-fang.The influence of metformin on HCY and IMT in newly diagnosed type 2 diabetes[J].Journal of Shandong University:Health Sciences,2011,49(7):6-8,14. |
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| Authors: | MI Nian-rong MENG Chao WANG Shu-fang |
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| Institution: | 1. School of Medicine, Shandong University, Jinan 250012, China;
2. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China |
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| Abstract: | Objective To investigate the changes of HCY(homocysteine) and IMT(intimal medial thickness) in newly diagnosed patients with type 2 diabetes mellitus(T2DM)before and after metformin,treatment and to explore the relationship between HCY and IMT.Methods Thirty type 2 diabetic patients and twenty healthy subjects were recruited.The T2DM subjects were given 1 500 mg/d metformin for one year.Changes of plasma HCY and IMT were determined before and after metformin treatment.Multivariate linear regression analysis... |
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| Keywords: | Metformin Type 2 diabetes mellitus Homocysteine Carotid intimal medial thickness |
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