| 蛇床子素抗变态反应的研究 |
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| 引用本文： | 陈志春,段晓波,刘堃荣. 蛇床子素抗变态反应的研究[J]. 药学学报, 1988, 23(2): 96-99 |
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| 作者姓名： | 陈志春 段晓波 刘堃荣 |
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| 作者单位： | 南京药物研究所 南京(陈志春，段晓波)，南京药物研究所 南京(刘堃荣) |
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| 摘 要： | 蛇床子素能较强地抑制小鼠被动皮肤过敏(PCA)反应,对整体豚鼠组胺性喘息具有保护作用,对慢反应物质(SRS-A)引起的豚鼠离体回肠收缩以及豚鼠离体回肠的Schultz-Dzle反应呈明显的拮抗和阻断作用,并能抑制大鼠腹腔肥大细胞脱颗粒。上述作用均呈一定的剂量依赖关系。
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| 关 键 词： | 蛇床子素 变态反应 被动皮肤过敏反应 慢反应物质 肥大细胞 |
| 收稿时间： | 1987-03-23 |
THE ANTI-ALLERGIC ACTIVITY OF OSTHOL EXTRACTED FROM THE FRUITS OF CNIDIUM MONNIERI (L.) CUSSON |
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| ZC Chen,XB Duan and KR Liu. THE ANTI-ALLERGIC ACTIVITY OF OSTHOL EXTRACTED FROM THE FRUITS OF CNIDIUM MONNIERI (L.) CUSSON[J]. Acta pharmaceutica Sinica, 1988, 23(2): 96-99 |
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| Authors: | ZC Chen XB Duan KR Liu |
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| Abstract: | The anti-anaphylactic activity of the osthol extracted from the fruits of Chidium monnieri (L.) Cusson was investigated. A single oral administration of osthol (100～200 mg/kg) inhibited the passive cutaneous anaphylaxis (PCA) reaction in mice and showed prominent protective effect against bronchial asthma induced by inhalation of histamine in conscious guinea pigs (P<0.01). In guinea pigs sensitized with egg albumin, significant inhibitory effect on spasmodic contraction of the guinea pigs ileum induced by antigen challenge in vitro was observed. At a concentration of 20 or 40 μg/ml, the substance blocked and counteracted the contractive activity of SRS-A on the isolated guinea pig ileum. Besides, osthol exhibited inhibitory effect on degranulation of mast cells, and the degree of inhibition was 78.6%. |
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| Keywords: | Osthol Allergy Passive cutaneous anaphylaxis response Slow reacting substance of anaphylaxia Mast cell |
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