糖化血红蛋白和C-反应蛋白与冠状动脉病变的相关性

目的探讨冠心病患者冠状动脉病变程度与血清糖化血红蛋白(HbA1c)、C-反应蛋白(CRP)水平之间的关系及其临床意义。方法 293例患者按照冠状动脉造影结果分为冠心病组及非冠心病组。冠心病组根据冠状动脉病变支数分为单支病变组、双支病变组、多支病变组,并根据Gensini积分对冠状动脉病变程度进行评分并分级,分析糖化血红蛋白及C-反应蛋白水平与冠状动脉病变的相关性。结果冠心病组血清CRP及HbA1c水平明显高于非冠心病组[(4.93±8.05)mg/L vs(2.21±2.70)mg/L,(5.73±1.28)%vs(5.28±0.78)%],差异均有统计学意义(P<0.05)。年龄、低密度脂蛋白、CRP及HbA1c与冠心病密切相关(OR=1.05～2.36,均P<0.05)。冠心病组CRP及HbA1c水平与Gensini积分呈正相关(r=0.12～0.15,均P<0.05)。结论 CRP及HbA1c联合检测对冠状动脉病变程度有较高的预测价值。

To study the Correlation between Serum Level of HbA1c and CRP and the Coronary Lesions in Patients with Coronary Heart Disease

Objective To study the correlation between the level of serum glycated hemoglobin(HbA1c),C-reactie protein(CRP) and the coronary lesions in patients with coronary heart disease.Methods 293 patients were divided into coronary heart disease(CHD) group(n=229) and the normal control group(n=64) to compare the level of HbA1c and CRP according to angiography results.The Gensini score was used to evaluate the severity of coronary stenosis,and the CHD group was divided into three groups again: single-artery lesions,double-artery lesions and multi-artery lesions.The coronary lesions was rated and classified by Gensini score,and the correlation between HbA1c and CRP was analysised via the evaluate tool.Results The serum levels of HbA1c and CRP in CHD group were higher than the control group[(4.93±8.05)mg/L vs(2.21±2.70)mg/L,(5.73±1.28)% vs(5.28±0.78)%,P<0.05].Age,LDL-C,CRP and HbA1c were related factors of CHD,CRP and HbA1c made the highest prediction value.The serum levels of CRP and HbA1c was positively correlated with Gensini score(r=0.12～0.15,P<0.05).Conclusions Higher level of CRP and HbA1c joint detection have significant predictive value for the severity of coronary stenosis.