缺血缺氧状态下细胞自噬相关分子机制的研究进展

细胞自噬是细胞依赖溶酶体的分解代谢过程,能降解受损蛋白、衰老或损伤的细胞器等细胞结构,可被多种应激所触发。在营养匮乏或组织缺血缺氧等应激条件下,自噬作为相应的代谢过程通过提供代用能源及清除功能异常的细胞器及蛋白质类维持细胞存活。缺血缺氧是细胞自噬激活的重要诱因之一,自噬的适度增强可促进细胞在缺血缺氧等状态下的存活。该文就细胞自噬的分子机制、缺血缺氧状态下自噬调控通路的调节机制及其分子水平检测技术的研究进展予以综述。

Research Progress of Cell Autophagy Related Molecular Mechanisms under Ischemia-hypoxia State

Autophagy is a cell degradation process dependent on lysosomes and has the role of cleaning up damaged proteins and senescent or damaged organelle, which can be triggered by diverse stimulus. It is becoming evident that autophagy protects cells, by providing an alternative energy source and by eliminating dysfunctional organelles or proteins in stressful conditions, such as nutrient deprivation and ischemia-hypoxia. Hypoxia-ischemic damage is a major inducer of autophagy. Large numbers of studies have shown that autophagy promotes cell＇s survival in starvation. Here is to make a review on morphological features of autophagy, the adjustment mechanism of autopbagy regulation pathways under ischemia-hypoxia state and the molecular level detection technology development.