| 载脂蛋白E基因多态性和脑梗死关系的研究 |
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| 引用本文： | 肖志杰,赵水平,聂赛,谭利民,蒋波,吴军,周宏年. 载脂蛋白E基因多态性和脑梗死关系的研究[J]. 卒中与神经疾病, 2004, 11(5): 259-261,267 |
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| 作者姓名： | 肖志杰 赵水平 聂赛 谭利民 蒋波 吴军 周宏年 |
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| 作者单位： | 1. 410011,长沙,中南大学湘雅二医院神经内科
2. 410011,长沙,中南大学湘雅二医院心内科 |
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| 摘 要： | 目的探讨载脂蛋白E基因(ApoE)多态性与脑梗死的关系.方法采用病例-对照研究,对379例脑梗死患者和351例对照组进行研究.采用聚合酶链式反应-限制性片段长度多态性方法测定ApoE基因多态性.结果脑梗死组ApoE基因型频率E3/3、E3/4、E3/2、E2/4和E4/4型分别为72.3%、14.5%、11.6%、0.8%、0.8%.在脑梗死组中未发现E2/2.E2/2在脑梗死组和对照组之间有显著性差异(P＜0.05.)结论ApoE2/2对脑梗死可能具有保护作用.
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| 关 键 词： | 载脂蛋白E 多态性 限制性片段长度 脑梗死 |
| 文章编号： | 1007-0478(2004)05-0259-03 |
Apolipoprotein E gene polymorphism in patients with cerebral infarction |
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| Xiao Zhijie,Zhao Shuiping,Nie Sai,et al.. Apolipoprotein E gene polymorphism in patients with cerebral infarction[J]. Stroke and Nervous Diseases, 2004, 11(5): 259-261,267 |
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| Authors: | Xiao Zhijie Zhao Shuiping Nie Sai et al. |
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| Affiliation: | Xiao Zhijie,Zhao Shuiping,Nie Sai,et al.Department of Neurology.Xiangya The Second Hospital of Central South University,Changsha 410011 |
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| Abstract: | Objective To investigate the correlation between the apolipoprotein E(ApoE) gene polymorphism and cerebral infarction.Methods In this case control study, we analyzed 379 cases with cerebral infarction and 351 controls without CHD and CVD.Polymerase chain reaction restricted fragments length polymorphism was used to determine ApoE gene polymorphism.Results The ApoE genotype frequencies in the cerebral infarction group were 72.3% for E3/3, 14.5% for E3/4, 11.6% for E3/2, 0.8% for E2/4, and 0.8% for E4/4 respectively.There was no ApoE2/2 genotype in the cerebral infarction group.Comprared with ApoE3/3 genotype,there was significant difference in ApoE2/2 genotype distribution between the cerebral infarction group and the control group( P < 0.05 ).Conclusions Our study suggests that the ApoE2/2 genotype has a protective effect on cerebral infarction. |
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| Keywords: | Apolipoprotein E Polymorphism Restriction fragment length Cerebral infarction |
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