CIK细胞与LAK细胞对H-22腹水瘤的抑瘤作用

目的 观察ＣＩＫ细胞及ＬＡＫ细胞对Ｈ－２２荷瘤鼠的抗肿瘤作用。方法 建立Ｈ－２２荷瘤鼠肿瘤动物模型，静脉输入ＣＩＫ细胞３周做抗肿瘤治疗，同时设ＬＡＫ对照；用同位素法检测，经治疗后荷瘤鼠Ｔ细胞增殖及ＮＫ细胞毒活性。结果 ＣＩＫ细胞对Ｈ－２２荷瘤鼠的抗肿瘤作用显著强于ＬＡＫ的细胞（抑瘤率分别是５４％ＶＳ２７％），并且ＣＩＫ疗法的抗作用可能与荷瘤鼠Ｔ细胞增活性增高有关。结论 ＣＩＫ细胞对Ｈ－２２荷瘤鼠的

Anti-tumor activity of CIK cells and LAK cells on the mice bearing H-22 tumor in vivo

Objective To evaluate the anti tumor activity of CIK (cytokine induced killer) cells on Kunming mice bearing H 22 tumor in vivo .Methods CIK cells were injected intravenously into the mice bearing H 22 tumor for 3 weeks and compared with LAK controls in the same time. Results CIK cells had significantly anti tumor effect (the median inhibitory rate was 54%) which was much higher than that of LAK cells(the median inhibitory rate was 27.1%); and the later experiment suggested that CIK therapy was correlated with inducing the proliferation of the mice spleen T cells other than the NK cytolytic activity. Conclusion CIK therapy was more effective on mice bearing H 22 tumor in vivo than that of LAK.