NT-proBNP在妊娠高血压心功能评估中的价值

目的探讨N-端脑利钠肽前体(NT-proBNP)在妊娠高血压疾病(PIH)心功能评估中的价值。方法将102例PIH孕妇分为妊娠高血压组37例,轻度子痫前期组33例,重度子痫前期组32例,另外选取正常妊娠组32例及正常未孕育龄妇女32例作为对照组,采用电化学发光法测定患者血清NT-proBNP浓度。结果 PIH组、正常妊娠组和对照组的NT-proBNP水平分别为(300.52±134.44)、(83.42±26.26)和(59.83±12.89)pg/ml,三者间比较差异均有统计学意义(P<0.01)。重度子痫前期组、轻度子痫前期组、妊娠高血压组的NT-proBNP水平分别为(488.56±155.54)、(323.39±148.90)和(185.73±43.78)pg/ml,三者间比较差异均有统计学意义(P<0.01)。NT-proBNP与孕妇体重指数(BMI)呈正相关(r=0.602),与新生儿体重呈负相关(r=-0.279)。结论孕后NT-proBNP有所升高,而且是能够用于评估PIH孕妇心功能的敏感指标之一。

The value of NT-proBNP assessment of cardiac function in pregnancy-induced hypertension

Objective To investigate whether N-terminal pro-brain natriuretic peptide(NT-proBNP) of pregnant women have value in evaluation of the cardiac function under pregnancy-induced hypertension(PIH).Methods 102 cases were assigned to three groups:pregnancy-induced hypertension women 37 patients,33 patients with mild preeclampsia,and 32 patients with severe preeclampsia.In addition,32 pregnant woman were selected as the normal pregnancy group,and 32 normal non-pregnant women as age control group.Serum NT-proBNP concentration was determined by electrochemiluminescence method.Results NT-proBNP concentrations in the PIH group,the normal pregnancy group and the control group were(300.52±134.44),(83.42±26.26) and(59.83±12.89)pg /ml,respectively.The difference between the first two groups and between the last two groups were significant(P <0.01).NT-proBNP levels in severe preeclampsia,mild preeclampsia,and gestational hypertension group were(488.56±155.54),(323.39±148.90) and(185.73±43.78)pg /ml.The differences among the three groups were significant(P<0.01).The NT-proBNP level was positively correlated to the BMI of pregnant women(r=0.602),but was negatively correlated to the birth weight of the baby(r=-0.279).Conclusion NT-proBNP level is increased after pregnancy and can be used as a sensitive indicator to assess the cardiac function of the PIH pregnant women.