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| 围生期接触磺胺二甲嘧啶对子代大鼠甲状腺功能的影响 | |
| 引用本文： | 王津涛,孙丁,邱云良,张浩,吴德生. 围生期接触磺胺二甲嘧啶对子代大鼠甲状腺功能的影响[J]. 卫生研究, 2010, 39(1) |
| 作者姓名： | 王津涛 孙丁 邱云良 张浩 吴德生 |
| 作者单位： | 1. 四川大学华西公共卫生学院,成都,610041 2. 成都市疾病预防控制中心 3. 上海医药工业研究院上海新药安全评价研究中心 |
| 基金项目： | 国家自然科学基金重点课题项目，纽约中华医学基金资助项目 |
| 摘 要： | 目的研究围生期母体接触磺胺二甲嘧啶对子代大鼠甲状腺功能的影响。方法受孕母鼠在受孕第7日起至哺乳期结束每天分别给予磺胺二甲嘧啶0、50、100和200mg/kg,HE染色观察20日龄子代大鼠甲状腺的组织病理学变化,并用免疫组织化学染色观察甲状腺内核增殖抗原的表达。结果各染毒剂量组子代大鼠甲状腺滤泡细胞出现不同程度的增生表现,核增殖抗原表达阳性细胞数显著高于对照组(P0.05)。结论磺胺二甲嘧啶可通过母体干扰子代大鼠甲状腺功能。 |
| 关 键 词： | 磺胺二甲嘧啶 甲状腺 核增殖抗原 |
Effects of perinatal exposure to sulphamethazine on the thyroid gland function of SD rats |
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| WANG Jintao,SUN Ding,QIU Yunliang,ZHANG Hao,WU Desheng. Effects of perinatal exposure to sulphamethazine on the thyroid gland function of SD rats[J]. Journal of hygiene research, 2010, 39(1) | |
| Authors: | WANG Jintao SUN Ding QIU Yunliang ZHANG Hao WU Desheng |
| Affiliation: | WANG Jintao,SUN Ding,QIU Yunliang,ZHANG Hao,WU Desheng Department of Environmental Health,West China School of Public Health,Sichuan University,Chengdu 610041,China |
| Abstract: | Objective To study the effect of perinatal exposure sulphamethazine on the function of thyroid gland of SD rats. Methods Dams were given sulphamethazine 0, 50, 100 and 200mg/(kg·d) respectively from gestational day (GD) 7 to postpartum day( P) 21. The sections of thyroid gland of pups 20 days after birth were stained by hematoxylin- eosin,and the expression of proliferating cell nuclear antigen (PCNA) were observed by immunohistochemistry staining. Results Compare with control, thyroid gland showed proliferation of follicular epithelium in each experimental group, and the numbers of PCNA positive cells in thyroid gland significantly higher than that of control (P < 0.05). Conclusion Perinatal exposure to sulphamethazine may affect the function of thyroid gland of offspring. |
| Keywords: | sulphamethazine thyroid gland |
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