急性一氧化碳中毒心肌酶谱与短期病死率相关性分析

目的探讨急性一氧化碳(CO)中毒患者心肌酶谱与短期病死率的相关性。方法选取我院2009年5月—2010年3月急诊入院的急性CO中毒患者98例,进行心肌酶谱临床数据观察,并比较与短期病死率的相关性。结果轻度CO中毒者心肌酶谱与对照组比较无统计学差异,中度、重度中毒者分别与轻度、中度中毒者比较,心肌酶谱显著增高;轻度、中度中毒者无死亡;重度中毒者中,死亡者的肌酸激酶(CK)、乳酸脱氢酶(LDH)、AST较存活者显著增高,肌酸激酶同工酶(CK-MB)无统计学差异。结论 CO中毒可致心肌损害。重度中毒者有一定病死率,并且心肌酶谱中CK、LDH、AST与短期病死率有相关性,对急性CO中毒的预后具有一定的诊断价值。

Analysis of correlation between myocardial zymogram and short-term mortality in patients with acute carbon monoxide poisoning

Objective To analyze the correlation between myocardial zymogram and short-term fatality rate in the victims of acute carbon monoxide poisoning.Methods A total of 98 acute carbon monoxide poisoning patients admitted to our hospital in an emergency between May 2009 and March 2010 were analyzed on the clinical data of myocardial zymogram and short-term mortality.Results There was no significant difference in myocardial enzyme spectrum between the mild carbon monoxide poisoning patients and normal controls.The myocardial enzyme spectrum was significantly higher in the moderate patients than in the mild ones,and significantly higher in the severe ones than in the moderate ones.None of the mild or moderate patients died.Among the severe patients,creatine kinase(CK),lactate dehydrogenase(LDH) and aspartate aminotransferase(AST) were significantly higher in the ones who died than in the survivals,between whom,creatine kinase isoenzyme(CK-MB) was of no significant difference.Conclusion Carbon monoxide poisoning causes myocardial damage.In severe poisoning patients,there exists certain mortality.Myocardial enzyme spectrum in CK,LDH and AST are positively correlated with short-term mortality,which has certain value in diagnosis and prognosis for acute carbon monoxide poisoning.