Biotransformation of bioactive isocaryolanes by Botrytis cinerea |
| |
Authors: | Ascari Jociani Boaventura Maria Amélia Diamantino Takahashi Jacqueline Aparecida Durán-Patrón Rosa Hernández-Galán Rosario Macías-Sánchez Antonio J Collado Isidro G |
| |
Institution: | Departamento de Qui?mica, Instituto de Cie?ncias Exatas, Universidade Federal de Minas Gerais, Avenida Presidente Anto?nio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil. |
| |
Abstract: | The metabolism of the fungistatic agent (8R,9R)-8-methoxyisocaryolan-9-ol (4) by the fungus Botrytis cinerea has been investigated. Biotransformation of compound 4 yielded compounds 5 and 6-9. No dihydrobotrydial is observed after 4 days of incubation of compound 4. Separate biotransformation of (8R,9R)-isocaryolane-8,9-diol (5) yielded compounds 7-11. The evaluation of the fungistatic activity against B. cinerea of compounds 4, 5, and 6 is reported. (4R,8R,9R)-8-Methoxyisocaryolane-9,15-diol (6), a major metabolite of (8R,9R)-8-methoxyisocaryolan-9-ol (4), shows a much reduced biological activity when compared with the parent compound. Isocaryolane derivatives 6-11 are described for the first time. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|