Combination chemotherapy of malignant glioma. Effect of postoperative treatment with CCNU, vincristine, amethopterine and procarbazine. |
| |
| Authors: | W D Heiss M Turnheim B Mamoli |
| |
| Affiliation: | 1. Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;2. Department of Neurology, Weill Cornell Medical College, New York, NY 10065, USA;1. Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;2. Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil;3. Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil;4. Departamento de Biologia Celular, Universidade Federal do Paraná, Curitiba, Brazil |
| |
| Abstract: | A combination chemotherapy consisting of CCNU, vincristine, amethopterine and procarbazine (COMP-therapy) was studied in the postoperative treatment of malignant gliomas. Fifteen-day COMP-therapy series given 10–20 days after surgery and repeated at regular intervals increased the median recurrence-free interval to 8.9 months and the median survival time to 10.7 months. Both prolongations were significant when compared to the results in a control group not receiving postoperative chemotherapy (median recurrence-free interval: 2.6 months, median survival time: 6.2 months), in a group receiving postoperative CCNU-treatment (3.5 and 6.5 months, respectively), and to a group of patients treated with postoperative polychemotherapy (4.7 and 8.0 months, respectively). The only problematic side effect of COMP-therapy was neuropathy resulting from toxic vincristine-dosage.While nitrosoureas alone were not able to affect the length and the quality of survival, their combination with cell-cycle specific and other cell-cycle non-specific drugs improved the results in the therapy of primary malignant brain tumors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
