模拟克山病病区低钙饲料对大鼠生长、代谢的影响

本文研究了模拟克山病病区易感人群膳食组成的饲料及在这种饲料中补充钙和硒对大鼠生长、代谢的影响。结果表明,模拟病区膳食的饲料中除低硒外低钙特别突出,所饲大鼠血清钙水平及全血GSH-Px酶活性明显低于常规饲料组;大鼠的生长状态、血清总蛋白及血清和心肌几种酶(GOT,GPT,LDH,α-HBDH,CK)活性均偏离常规饲料组。在模拟病区膳食的饲料中单纯补充钙可明显改善大鼠的生长状态和酶活性的偏移,呈规律性趋向常规饲料组。表明低钙在喂养病区膳食的大鼠所造成的生长迟缓、代谢偏移中起重要作用。补充钙同时补充硒效果更好。结合流行病学资料表明在低硒环境下合并有明显的低钙,可引起克山病发病。

EFFECTS OF LOW CALCIUM OF MONOTONOUS DIET FROM KESHAN DISEASE DISTRICT ON GROWTH AND METABOLISM OF RATS

The effects of mimic endemic monotonous diet (EM diet) susceptible to Keshan disease and that supplemented with Ca or/and Se on growth and metabolism of rats were studied. The results demonstrated that Ca content in the monotonous diet consisted of grains cultivated from Keshan disease district was low prominently as well as Se. The serum Ca level and blood GSH-Px activity of rats kept on the EM diet were significantly lower than those of rats kept on stock diet. The growth rate and serum total protein were significantly lower than those of the rats kept on stock diet, and the activities of several enzymes (GOT, GPT, LDH, α-HBDH, CK) were obviously deviated. When the EM diet was supplemented with Ca alone, the growth rate and enzymes activity deviation were significantly improved and regularly approached to those of the stock diet group. In the growth retardation and metabolism deviation induced by EM diet,low Ca played an impor-tant role. When the endemic diet was supplemented both Ca and Se the result was better. As associated with the epidemiological data, it is suggested that in the Se deficient endemic area the incidence of Keshau disease will be enhanced if the EM diet was combined with severely low Ca under certain condition.