短暂脑缺血发作患者血小板膜糖蛋白CD62P表达及其意义

目的：探讨短暂脑缺血发作（TIA）患者外周血小板膜糖蛋白CD62P表达的临床意义及阿司匹林对血小板表面膜糖蛋白的作用。方法：应用流式细胞术测定30例TIA患者CD62P的分子表达，包括进展（9例）及未进展（21例）为脑梗塞患者，并依其是否常规口服阿司匹林将其分为口服组(12例)和未口服组(18例)，将TIA患者组内及患者与26例健康成年人所测结果进行比较。结果：CD62P在健康成人表达较低，阳性率为（30.17±3.55）％，而TIA患者阳性率为（65.23±21.11）％，其中进展为脑梗塞患者阳性率为（68.21±2.42）％，未进展为脑梗塞的患者阳性率为（60.07±3.46）％。在TIA患者中，常规口服阿司匹林（＞6个月）的血小板活化率为（60.75±2.03）％，未服用阿斯匹林的患者血小板活化率为（70.01±3.43）％。结论：CD62P能较好地反映血小板活化程度并可较早地预测、估计TIA演变趋势；阿司匹林对CD62P的表达可能有抑制作用。

Expression of platelet membrane glycoproteins CD62P and its significance in patients with transient ischemic attack

Objective To study the expression of platelet membrane glycoproteins (MG) CD62P in peripheral blood in patients with transient ischemic attack (TIA) and its clinical significance, and the effects of aspirin on platelet MG. Methods The CD62P expressions of 30 cases of TIA patients were measured with flow cytometry (FCM), including patients (9 cases) with progressing to infarction and non-progressing (21 cases). Whether taking aspirin orally or not, samples were divided into 2 groups (the former 12 cases, the latter 18 cases). And the results between groups and between the patients and healthy volunteers were compared. Results The expression of CD62P in healthy volunteers was lower, the positive rate was (30.17±3.55)% while that of TIA patients was higher, the positive rate was (65.23±21.11)%, among which positive rate of patients progressing to infarction was (68.21±2.42)% and that of non-progressing patients was (60.07±3.46)%. After TIA patients took orally aspirin more than 6 months regularly, the activation rate of platelet was (60.75±2.03)%. Patients without aspirin taken orally had a platelet activation rate of (70.01±3.43)%. Conclusion CD62P is able to reflect the activation level of platelet so as to forecast the onset of TIA and to estimate its evolvement trend; aspirin may play a suppressive effect on CD62P expression.