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| 急性一氧化碳中毒后迟发性脑病患者血清NO与NOS水平及其临床意义 | |
| 引用本文： | 孙伟力,王冀康,李时光,李文强,顾仁骏,张萍,张帆,王夏红,师天元,张红亚,赵建华,石金河,陈希妍,张建新,靳玫.急性一氧化碳中毒后迟发性脑病患者血清NO与NOS水平及其临床意义[J].中国神经精神疾病杂志,2011,37(9). |
| 作者姓名： | 孙伟力 王冀康 李时光 李文强 顾仁骏 张萍 张帆 王夏红 师天元 张红亚 赵建华 石金河 陈希妍 张建新 靳玫 |
| 作者单位： | 1. 新乡医学院第二附属医院神经内科 2. 河南省生物精神病学重点实验室 3. 郑州市第一人民医院神经内科 4. 新乡医学院第一附属医院 5. 新乡医学院第三附属医院神经内科 |
| 基金项目： | 河南省教育厅自然科学研究资助项目 |
| 摘 要： | 目的 探讨血清一氧化氮(nitric oxide,NO)、一氧化氮合酶(nitric oxide synthsae,NOS)的水平及其动态变化与急性一氧化碳中毒后迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)患者病情变化的关系.方法 应用比色法(colorimetric method)动态测定31例DEACMP患者血清NO及NOS水平,并与30例急性一氧化碳中毒(acute carbon monoxide poisoning,ACMP)后未发生迟发脑病患者和30 例正常对照进行比较.结果 DEACMP患者急性期血清NO及NOS水平(62.67 ± 14.39)μmol/L,(27.68 ± 6.14)U/mL]明显高于正常对照组(50.18 ± 9.95) μmol/L,(20.88 ± 6.32)U/mL] (均P ＜ 0.05),与ACMP组急性期(62.00 ± 16.46)μmol/L,(28.13 ± 5.23)U/mL]比较无统计学差异(均P ＞ 0.05);DEACMP患者恢复期血清NO及NOS水平(54.66 ± 11.73)μmol/L,(21.74 ± 5.88)U/mL]明显低于急性期(均P ＜ 0.05),与ACMP组随访期(52.79 ± 11.22)μmol/L,(20.64 ± 5.92)U/mL]比较无统计学差异(均P ＞ 0.05).结论 NO-NOS系统参与了DEACMP的发病机制,NO-NOS水平变化与病情变化基本一致. |
| 关 键 词： | 一氧化碳中毒 脑病 一氧化氮 一氧化氮合酶 |
Clinical significance of serum levels of NO and NOS in patients with delayed encephalopathy after acute carbon monoxide poisoning |
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| SUN Weili,WANG Jikang,LI Shiguang,LI Wenqian,GU Renjun,ZHANG Ping,ZHANG Fan,WANG Xiahong,SHI Tianyuan,ZHANG Hongya,ZHAO Jianhua,SHI Jinhe,CHEN Xiya,ZHANG Jianxin,JIN Mei.Clinical significance of serum levels of NO and NOS in patients with delayed encephalopathy after acute carbon monoxide poisoning[J].Chinese Journal of Nervous and Mental Diseases,2011,37(9). | |
| Authors: | SUN Weili WANG Jikang LI Shiguang LI Wenqian GU Renjun ZHANG Ping ZHANG Fan WANG Xiahong SHI Tianyuan ZHANG Hongya ZHAO Jianhua SHI Jinhe CHEN Xiya ZHANG Jianxin JIN Mei |
| Institution: | SUN Weili,WANG Jikang,LI Shiguang,LI Wenqian,GU Renjun,ZHANG Ping,ZHANG Fan,WANG Xiahong,SHI Tianyuan,ZHANG Hongya,ZHAO Jianhua,SHI Jinhe,CHEN Xiya,ZHANG Jianxin,JIN Mei.Department of Neurology,the Second Affiliated Hospital of Xinxiang Medical University,388 Jian-she Road,Xinxiang 453002 China. |
| Abstract: | Objective To investigate the association between serum nitric oxide(NO),nitric oxide synthsae(NOS) level and their dynamic changes versus condition changes in patients with delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods By using colorimetric method,the serum NO and NOS level in 31 patients with DEACMP were determined,in comparison with those in 30 patients of acute carbon monoxide poisoning without DEACMP and 30 normal controls,respectively.Results The serum NO and NOS levels ... |
| Keywords: | Carbon monoxide poisoning Encephalopathy NO NOS |
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