Motor coordination and spatial orientation are affected by neurofilament maldistribution: correlations with regional brain activity of cytochrome oxidase |
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Authors: | R Lalonde M Dubois C Strazielle J Eyer |
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Institution: | Université de Rouen, Faculté des Sciences, UPRES PSY.CO-1780, Laboratoire de Neurobiologie de l’Apprentissage, F-76821 Mont-Saint-Aignan Cedex, France, FR INSERM CJF 97-08, CHU Batiment Monteclair, Université d’Angers, F-49033 Angers Cedex, France, FR
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Abstract: | NFH-LacZ transgenic mice are characterized by an early accumulation of the neurofilament cytoskeleton in the cell bodies
of neurons with age-associated abnormalities of motor neurons and cerebellar Purkinje cells. In comparison to normal littermate
controls, irrespective of age (3 and 12–20 months), NFH-LacZ transgenic mice had a lower number of rears in an open field,
deficiencies in some motor-coordination tests, and a higher number of quadrant entries and escape latencies while swimming
toward a visible platform. Decreased cytochrome oxidase activity in the lateral reticular nucleus of NFH-LacZ mice was associated
with poor performance in two motor coordination tests. Lower metabolic activity in the lateral reticular nucleus may be secondary
to previously described cerebellar abnormalities, leading to deficient motor control. The dramatic cytoskeletal perturbation
characterizing NFH-LacZ mice affects only selective neuronal populations and results in selective behavioral deficits, which
can be correlated with regional brain metabolic activity.
Received: 10 July 1998 / Accepted: 28 December 1998 |
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Keywords: | Neurofilaments Cerebellum Motor neuron Spatial learning Motor coordination Motor activity Brain metabolism Cytochrome oxidase |
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