| 充血性心力衰竭大鼠模型的制作及意义 |
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| 引用本文： | 高琴,关瑞锦.充血性心力衰竭大鼠模型的制作及意义[J].心血管康复医学杂志,2004,13(1):27-30. |
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| 作者姓名： | 高琴 关瑞锦 |
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| 作者单位： | 福建省立医院心血管病研究所,福建,福州,350001 |
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| 摘 要： | 目的：建立大鼠心肌梗死后心力衰竭的动物模型，深入心衰机制的研究。方法：通过结扎大鼠冠状动脉左主干，使心室壁发生梗死，长期饲养(6周)，建立心梗后慢性心力衰竭模型，并与同期的假手术组比较，观察术后大鼠临床表现、心电图、血液动力学变化及心梗区域大小。结果：手术组术后成活率52．5％，心梗后6周出现失代偿性心衰。结论：此方法有效且重复性好，可较理想地模拟心梗后慢性充血性心力衰竭的发生，对研究心衰机制有重要意义。
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| 关 键 词： | 充血性心力衰竭 大鼠模型 心力衰竭 心肌梗死 心脏疾病 |
| 文章编号： | 1008-0074(2004)01-0027-04 |
| 修稿时间： | 2003年9月14日 |
Significance and establish methods of experimental rat model with congestive heart failure |
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| GAO Qin,GUAN Rui-jin//Fujian Provincial Hospital,Fuzhou . Fujian. ,China.Significance and establish methods of experimental rat model with congestive heart failure[J].Chinese Journal of Cardiovascular Rehabilitation Medicine,2004,13(1):27-30. |
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| Authors: | GAO Qin GUAN Rui-jin//Fujian Provincial Hospital Fuzhou Fujian China |
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| Institution: | GAO Qin,GUAN Rui-jin//Fujian Provincial Hospital,Fuzhou . Fujian. 350001,China |
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| Abstract: | Objective: To establish a chronic congestive heart failure rat model,Methods: Left coronary artery of rat was legated to cause left heart failure after myocardial infarction. Then electrocardiogram change, left ventricular hemodynamics and area of the infarction were observed and measured in six weeks. Results: Compared with sham-operated group the LVEDP increased, LVSP, LVdp/dtmax - dp/dtmax decreased (P<0. 01) in operated group. Conclusion:The model is effective and repeated, may ideally mimic heart failure after myocardial infarction, and is important for research of heart failure. |
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| Keywords: | Sprague-dawley rat Heart failure Animal model Myocardial infarction |
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