高原地区部队官兵腰椎间盘突出症患者血清SOD、MDA表达及临床意义

目的:通过检测高原地区部队官兵腰椎间盘突出症(lumbar disc herniation,LDH)患者血清中超氧化物歧化酶(SOD)的活力值及丙二醛(MDA)含量,探讨低氧环境下氧自由基对腰椎间盘突出症发病的影响。方法:采集腰椎间盘突出症患者血清标本作为患病组,共27例,随机抽取高原驻军健康机体血清标本27例为对照组,服役年限均为2～5年。取入伍1周的新兵血清标本27例为标准组进行比较。结果:27例腰椎间盘突出症患者血清中SOD活力值低于对照组高于标准组(P<0.05)。患病组血清中MDA高于对照组及标准组(P<0.05)。结论:高原地区部队官兵腰椎间盘突出症患者存在着不同程度的氧自由基代谢失衡,主要表现为清除超氧阴离子自由基的SOD活性下降,氧自由基含量的升高。氧自由基是加速椎间盘退变和致痛的重要因素。

Expression of SOD and MDA and its clinical significance for soliders with lumbar disc herniation at high altitute

Objective: To investigate the effect of oxygen radicals on the development of lumbar disc herniation(LDH) in hypoxic environment by examining the activity of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in soliders with lumbar disc herniation(LDH) at plateau area.Methods: The serum were obtained from the officers and soliders with LDH(the disease group) and the healthy people(the control group).The new comers from plain area were used as standard group.Those of the disease group and the control group must had been stayed on plateau for 2-5 years.Twenty-seven people were included in each group.Results: The SOD activity in the disease group was lower than that of the control group but higher than that of the standard group(P<0.05).The contents of MDA in the disease group were higher than those of the control group and the standard group(P<0.05).Conclusion: The oxidation and anti-oxidation system are imbalanced in the patients with LDH in plateau and the oxygen-derived free radicals are the important factors for the acceleration of disc degeneration and the occurrence of pain.