整合素对生殖生理作用的研究进展 |
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引用本文: | 卢桂兰,武玉玲. 整合素对生殖生理作用的研究进展[J]. 解剖科学进展, 2004, 10(2): 177-181 |
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作者姓名: | 卢桂兰 武玉玲 |
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作者单位: | 北京市疾病预防控制中心传染病与地方病控制所,北京,100013;山东大学医学院组织胚胎学教研室,山东,济南,250012 |
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基金项目: | 山东省自然科学基金资助课题 (No Y2 0 0 1C3 3 ) |
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摘 要: | 整合素是普遍存在于细胞表面的跨膜糖蛋白 ,其主要功能是粘附和信号传递。整合素参与受精过程 ,部分整合素在子宫内膜的表达有明显的周期性变化 ,与“着床窗”的开放相吻合 ;胚胎着床后 ,滋养层细胞能及时调整整合素的表达。整合素还参与胚胎的生长发育、胎盘的形成 ;整合素在生殖生理过程中发挥重要作用。
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关 键 词: | 整合素 生殖生理 受精 胚胎植入 蜕膜 |
文章编号: | 1006-2947(2004)02-0177-05 |
修稿时间: | 2003-03-06 |
The Research Progress on the Role of Integrins in Reproductive Physiology |
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Abstract: | Integrins, present essentially on the surface of cells, are transmembrane glycoproteins that function as cell adhesion and transduction of signals. Integrins participate in fertilization, some of integrins have spatial and temporal changes of expression in the cycling endometrium, corresponding to "implantation window". Subsequent to implantation, the expression of integrins could be timely modulated by trophoblast. Furthermore, they are also involved in the process of embryonic development and placetation. In summary, integrins play a critical physiological role in reproductive system. |
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