| 胰腺癌组织中SDF-1的表达与其临床病理特征的关系 |
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| 引用本文： | 王宝胜,孟祥鹏,刘臻,孙韶龙,姜卫国,戴显伟. 胰腺癌组织中SDF-1的表达与其临床病理特征的关系[J]. 陕西肿瘤医学, 2012, 0(3): 540-542 |
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| 作者姓名： | 王宝胜 孟祥鹏 刘臻 孙韶龙 姜卫国 戴显伟 |
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| 作者单位： | [1]中国医科大学附属盛京医院胰腺甲状腺外科,辽宁沈阳110004 [2]中国医科大学附属盛京医院病理科,辽宁沈阳110004 |
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| 摘 要： | 目的：探讨SDF-1在人胰腺癌组织中的表达及与临床病理特征之间的关系。方法：应用免疫组织化学方法检测64例胰腺癌组织及24例正常组织中SDF-1的表达。结果：胰腺癌组织的SDF-1表达在不同组织学分级之间有显著差异,中-低分化组中SDF-1表达率明显高于高分化组（P〈0.05）。结论：SDF-1可能在胰腺癌侵袭性进展中起到一定作用,有可能作为评价胰腺癌预后的生物学指标。
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| 关 键 词： | 基质细胞衍生因子-1 胰腺肿瘤 免疫组织化学 |
Expression of stromal cell derived factor 1 in pancreatic cancer tissues and its relationship with clinicopathological characteristics |
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| WANG Baosheng,MENG Xiangpeng,LIU Zhen,SUN Shaolong,JIANG Weiguo,DAI Xianwei. Expression of stromal cell derived factor 1 in pancreatic cancer tissues and its relationship with clinicopathological characteristics[J]. Shaanxi Oncology Medicine, 2012, 0(3): 540-542 |
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| Authors: | WANG Baosheng MENG Xiangpeng LIU Zhen SUN Shaolong JIANG Weiguo DAI Xianwei |
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| Affiliation: | 1 Department of Pancreatic and Thyroid General Surgery,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China;2 Department of Pathology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China |
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| Abstract: | Objective：To investigate the expression of SDF-1 and its clinical significance in human panreatic cancer.Methods：The expression of SDF-1 in 64 samples of human pancreatic cancer and 24 samples of normal human pancreatic tissues were detected by immunohistochemistry method.Results：The expression of SDF-1 correlated with histological grades,expression rate of SDF-1 in group of moderate-low differentiation was significantly higher than that in group of well differentiation（P 0.05）.Conclusion：The high expression of SDF-1 may play a certain effect in invasion and metastasis in human pancreatic cancer and SDF-1 may serve as an useful prognostic marker for human pancreatic cancer. |
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| Keywords: | SDF-1 pancreatic neoplasms immunohistochemistry |
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