Lewisy抗原及IGF-1R在卵巢黏液性肿瘤中的表达及意义

目的：探讨Lewis y抗原及胰岛素样生长因子受体-1（IGF-1R）在卵巢黏液性肿瘤中表达规律及其相关性。方法：用免疫组化法检测62例卵巢黏液性肿瘤和20例正常卵巢组织中Lewis y抗原与IGF-1R的表达,并分析其表达与卵巢癌病理分级、临床分期及淋巴结转移的关系。结果：Lewis y在恶性、交界性、良性和正常组的阳性表达率分别是90.0%、70.6%、53.3%和0%,呈下降趋势,其中恶性与交界性,良性和正常组比较差异有统计学意义（P〈0.05）;IGF-1R在恶性、交界性、良性和正常组的阳性表达率分别是93.3%、70.6%、46.7%和40.0%,呈下降趋势,其中恶性与交界性,良性和正常组比较差异有统计学意义（P〈0.05）;Lewis y抗原或IGF-1R的阳性表达率与卵巢黏液癌临床病理参数无关（P均〉0.05）;Lewis y抗原和IGF-1R的表达水平随临床分期的增加,但无统计学意义（P〉0.05）、随分化程度的降低而增加（P〈0.05）,与有无淋巴结转移无关（P〉0.05）;Lewis y抗原和IGF-1R在卵巢黏液性囊腺癌中的表达呈显著正相关（r=0.711,P〈0.005）。结论：随着卵巢黏液性肿瘤的恶性进展Lewis y抗原及IGF-1R的表达上调,且两者的表达呈显著性正相关。提示Lewis y抗原及IGF-1R对卵巢黏液性囊腺癌的转移、分化起促进作用。

Expression and significance of Lewis y and IGF - 1R in ovarian mucinous tumors

Objective：To investigate the expression and the clinical significance of Lewis y antigen and insulin like growth factor receptor 1（IGF-1R） in ovarian mucinous tumors.Methods：A total of 62 paraffin-embedded specimens of primary ovarian mucinous tumors and 20 paraffin-embedded specimens of primary ovarian tissues were collected.Inmunihistochemistry was performed to determine the localization and patterns of Lewis y antigen and IGF-1R protein expression.Results：The cytoplasmic expression rates of Lewis y in malignant,borderline,benign and normal group were 90.0%,70.6%,53.3% and 0%,respectively,which presents a declining trend.There was significant difference of Lewis y between malignant vs.borderline,benign tumors and normal tissues（P 0.05）.The expression rates of IGF-1R in malignant,borderline,benign and normal group were 93.3%,70.6%,46.7% and 40.0%,respectively,which presents a declining trend.There was significant difference of IGF-1R between malignant vs.borderline,benign tumors and normal tissues（P 0.05）.Increased expression of Lewis y and IGF-1R correlated with differentiation degree,but were not associated with clinical stage and lymphatic metastasis（P 0.05）.The expression intensity of Lewis y and IGF-1 R was significantly differente with differentiation degree（all P 0.05） in ovarian mucinous cancer.There was positive correlation between Lewis y and IGF-1R（r = 0.711,P 0.005）.Conclusion：With the malignant development of ovarian mucinous tumors,the expression of Lewis y and IGF-1R are up-regulated,and the positive correlations consist between them.These results suggest that Lewis y and IGF-1R may play an important role in the proliferation and differentiation of ovarian mucinous cancer.