| Syk基因甲基化在肝癌中的研究进展及展望 |
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| 引用本文： | 周静,高曰文,胡汉卿. Syk基因甲基化在肝癌中的研究进展及展望[J]. 陕西肿瘤医学, 2012, 0(2): 430-432 |
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| 作者姓名： | 周静 高曰文 胡汉卿 |
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| 作者单位： | 三峡大学第一临床医学院＆湖北省宜昌市中心人民医院普外科,湖北宜昌443002 |
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| 摘 要： | 脾酪氨酸激酶（spleen tyrosine kinase,Syk）是一种造血细胞特异性的信号分子,被认为是一种候选抑癌基因。DNA甲基化是肿瘤发生发展过程中较常见的表观遗传学改变,它与肿瘤的关系己成为肿瘤发病机制研究中的热点。本文综述了Syk基因甲基化的研究现状和它在肝癌中的表达情况及其与肿瘤发生、发展、转移的关系。
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| 关 键 词： | Syk基因 DNA甲基化 肝癌 |
The research progress and prospect of Syk gene methylation in liver cancer |
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| ZHOU Jing,GAO Yuewen,HU hanqing. The research progress and prospect of Syk gene methylation in liver cancer[J]. Shaanxi Oncology Medicine, 2012, 0(2): 430-432 |
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| Authors: | ZHOU Jing GAO Yuewen HU hanqing |
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| Affiliation: | The First Clinical Medical College of China Three Gorges University Yichang,Hubei Yichang 443002,China |
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| Abstract: | Spleen tyrosine kinase（Syk）is a kind of specific signaling molecule of hematopoietic cells,which is considered a new candidate tumor suppressor gene.DNA methylation in cancer development process is relatively common epigenetic alterations it has become a hotspot in mechanism study of tumour.This paper reviews the research of Syk gene methylation in hepatocellular carcinoma with cancer occurrence,development and transfer relationship. |
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| Keywords: | syk gene DNA methylation liver cnacer |
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