老年高血压患者C反应蛋白水平与颈动脉内中膜厚度相关性及辛伐他汀的干预研究

目的研究老年高血压患者C反应蛋白水平与颈动脉内中膜厚度相关性及辛伐他汀的干预作用。方法入选200例老年高血压患者,随机分为三组:对照组(安慰剂)、辛伐他汀组(辛伐他汀20 mg,qn)、非洛贝特组(非洛贝特200 mg,bid),分别于服药前、服药后3个月和6个月检测血浆C反应蛋白水平、颈动脉内中膜厚度、血浆胆固醇及甘油三酯浓度,探讨不同程度颈动脉内中膜厚度患者的C反应蛋白水平。并且通过比较不同药物治疗前后的C反应蛋白水平与颈动脉内中膜厚度,研究辛伐他汀对老年高血压患者动脉粥样硬化的干预作用。结果老年高血压患者随着颈动脉内中膜厚度的增加,C反应蛋白水平相应升高。应用辛伐他汀可降低老年高血压患者的C反应蛋白水平和颈动脉内中膜厚度,结果表明辛伐他汀能够有效控制老年高血压患者动脉粥样硬化程度,抑制动脉粥样硬化炎症反应。结论对于老年高血压患者,C反应蛋白水平与颈动脉内中膜厚度具有明显相关性,可以作为评价动脉粥样硬化程度的简便指标进行推广。而辛伐他汀可明显抑制动脉粥样硬化炎症反应,降低老年高血压患者的动脉粥样硬化水平。

Correlation between C reactive protein and carotid artery intima-media thickness in elderly hypertensive patients and the intervention with simvastatin

Objective To study the correlation between level of C reactive protein in elderly hypertensive patients with their carotid artery intima media thickness and the effect of simvastatin intervention.Methods Two hundred cases of elderly patients with hypertension were randomly divided into three groups：control group（placebo）,simvastatin group（simvastatin for 20 mg,qn）,of fenofibrate group（of fenofibrate 200 mg,bid）,respectively,before taking medicine,three month and six month after taking drug.Plasma C reactive protein concentration,carotid intima-media thickness,plasma cholesterol and triglyceride concentrations were detected.Different degrees of C reactive protein concentration were explored.By comparing C reactive protein and carotid artery intima-media thickness before and after treatment,study of simvastatin on atherosclerosis in elderly hypertension patients and the intervention effect of it was condncted.Results In elderly hypertensive patients with the increase of carotid artery intima-media thickness,C reactive protein concentration rose.Simvastatin could reduce C reactive protein concentration and carotid artery intima-media thickness,which showed that simvastatin could effectively control the degree of atherosclerosis in elderly patients with hypertension,inhibited atherosclerosis inflammation.Conclusion For elderly hypertensive patients,C reactive protein concentration and carotid artery intima-media thickness has significant correlation,which can be used as evaluation index for atherosclerosis.Simvastatin can inhibit atherosclerosis inflammation,reduce atherosclerotic level in elderly hypertensive patients.