膀胱癌病人乙酰基转移酶表型的研究

应用ＤＤＳ作为实验药物，采用高效液相色谱法，研究了目前尚存话的有２－萘胺职业接触史的１１名膀胱癌病人、２５名普通膀胱癌病人及２３名接触对照的ＮＡＴ酶表型。结果表明。无论有无２－萘胺职业接触史，膀胱癌病人中慢型乙酰化者所占比例（５２．２％和４５．５％）均高于对照组（１３．０％），且差异有显著性（Ｐ＜０．０５），比值比０Ｒ分别为５．５６（９５％可信限＝１．０２～３０．３）和７．２５（９５％可信限＝１．７０～３０．３），提示慢型乙酰化者若暴露于２－萘胺更易患膀胱肿瘤，乙酰化慢表型是膀胱癌的一个遗传易感因素。

Study of acetylator phenotype in bladder cancer patients

11 alive occupational 2-naphthylamine exposed bladder cancer patients,25 non-occupational exposed bladder cancer patients and 23 exposed controls were included for study of acetylator phenotype.DDS was used as test drug for determination of acetylator phenotype employing HPLC.The results showed that both the occupational and non-occupational exposed group were predominantly slow acetylators(52．2％and 45.5％),higher than that in the exposed controls(13.0％)(0<0 05).The risks for bladder cancer with the slow acetylator phenotype are OR=5.56（95％CI=1.02-30.3)and OR=7.25(95％CI=1.70-30.3)respectively.It is suggested that slow acetylator subjects are more susceptible to bladder tumour development when exposed to 2-naphthylamine. Slow acetylator phenotype was one of the genetic risk factors,