Cognitive performance and cigarette smoking in first-episode psychosis |
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Authors: | Arantzazu Zabala José Ignacio Eguiluz Rafael Segarra Sonsoles Enjuto Jesús Ezcurra Ana González Pinto Miguel Gutiérrez |
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Institution: | Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, University of the Basque Country (UPV-EHU), Apdo. Correos 699, 48080, Vizcaya, Spain. azabala@mce.hggm.es |
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Abstract: | The purpose of this study is to describe possible differences in cognitive functioning between smoking and non-smoking patients
with first-episode psychosis and to determine whether there is a better cognitive profile associated with smoking. We assessed
61 first-episode psychosis patients with a neuropsychological battery that included computerized measurements of attention,
working memory, and executive functioning. Patients were grouped into two categories: non-smokers (0 cigarettes/day; n = 30) and smokers (≥20 cigarettes/day; n = 31). No significant differences were detected in sociodemographic and clinical data between the two groups. For attention
tasks, smokers exhibited shorter reaction times in the sustained attention test than non-smokers (P = 0.039) and needed less time to complete the Stroop interference test (P = 0.013). In the working memory task, smokers exhibited shorter reaction times (P = 0.029) and presented a significantly lower percentage of omission (P = 0.002) and commission errors (P = 0.020) than non-smokers. For executive functioning, no differences were detected between groups in performance on the Wisconsin
Card Sorting Test. Results indicate that first-episode psychosis patients who are nicotine users have better cognitive functioning
in the areas of attention and working memory than patients who are not nicotine users. This study supports the cognitive approach
to the self-medication hypothesis, to explain the high rates of cigarette smoking among psychosis patients. These results
may be relevant for developing new strategies involving nicotinic receptors for cognitive enhancement in psychosis. |
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Keywords: | cognition nicotine smoking first episode psychosis |
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