异丙酚对犬急性心肌缺血再有灌注损伤时血流动力学的影响

目的研究不同剂量的异丙酚对犬急性心肌缺血再灌注损伤时血流动力学的影响。方法杂种家犬18只随机分为NS组(生理盐水对照组，2ml

Effects of propofol onhemodynamic of acute myocardial ischemia- reperfusion injury

Objective To evaluate the effects of propofol on hemodynamics of acute myocardial ischemia - repeffusion injury. Methods 18 hybrid dogs were divided randomly into NS group ( Normal Saline , 2ml·kg-1·h-1), HP group(High-dosePropofol, 11.2mg·kg- 1· h - 1 ) and LP group ( Low - dose Propofol, 5.6 mg· kg- 1 · h - 1 ). These dogs were subjected to a 90 - min left anterior descending coronary artery (LAD) occlusion followed by 200 min of reperfusion. Before administration, at 60 - min after administration, at occlusion - 90 min and reperfusion - 60 min, - 120 min, - 180 min, the parameters of hemodynamics was assessed by measurement of HR, MAP, CVP, SVR,PAP, PCWP, PVR and CI. Results The change of HR caused by acute myocardial ischemia- reperfusion injury in HP and LP group was smaller than that in NS group. The values of MAP at occlusion - 90 min decreased 27% compared with the baseline ( P ＜ 0.05). The parameters of pulmonary circulation include PAP, PCWP and PVR increased obviously at occlusion - 90 min and repeffusion - 60 min, - 120 min,- 180 min. At 120 - min and 180 min after repeffusion the values of CI in HP and LP group were similar to the values before occlusion, but significantly higher than those in NS group ( P ＜ 0.05) at the same time. Conclusion Propofol can reduce the changes of HR, and protect the function of systemic circulation, pulmonary circulation and CI during acute myocardial ischemia - repeffusion injury in a canine model.